Zhang Huafeng, Sun Bingwei
Department of Burns and Plastic Surgery, Affiliated Hospital, Jiangsu University, Zhenjiang, 212001, Jiangsu, China.
Inflamm Res. 2017 Mar;66(3):197-207. doi: 10.1007/s00011-016-0993-3. Epub 2016 Sep 30.
Sepsis is a complex clinical condition that causes a high mortality rate worldwide. Numerous studies on the pathophysiology of sepsis have revealed an imbalance in the inflammatory network, thus leading to tissue damage, organ failure, and ultimately death. The impairment of neu-trophil migration is associated with the outcome of sepsis.
Literature review was performed on the roles of neutrophil recruitment and neutrophil receptors as pleiotropic regulators during sepsis. Additionally, we systematically classify neutrophil receptors with regard to the neutrophil response during sepsis and discuss the clinical implications of these receptors for the treatment of sepsis.
Increasing evidence suggests that there is significant dysfunction in neutrophil recruitment during sepsis, characterized by the failure to migrate to the site of infection. Neutrophil receptors, as pleiotropic regulators, play important roles in the neutrophil response during sepsis.
Neutrophil receptors play key roles in chemotactic neutrophil migration and may prove to be suitable targets in future pharmacological therapies for sepsis.
脓毒症是一种复杂的临床病症，在全球范围内导致高死亡率。众多关于脓毒症病理生理学的研究揭示了炎症网络的失衡，进而导致组织损伤、器官衰竭，并最终导致死亡。中性粒细胞迁移受损与脓毒症的预后相关。
对中性粒细胞募集和中性粒细胞受体在脓毒症期间作为多效性调节因子的作用进行了文献综述。此外，我们根据脓毒症期间中性粒细胞的反应对中性粒细胞受体进行了系统分类，并讨论了这些受体对脓毒症治疗的临床意义。
越来越多的证据表明，脓毒症期间中性粒细胞募集存在明显功能障碍，其特征是无法迁移到感染部位。中性粒细胞受体作为多效性调节因子，在脓毒症期间的中性粒细胞反应中发挥重要作用。
中性粒细胞受体在趋化性中性粒细胞迁移中起关键作用，可能被证明是未来脓毒症药物治疗的合适靶点。
