1996年至2012年意大利东北部二氨基二苯甲烷致敏情况
Diaminodiphenylmethane Sensitization in north-eastern Italy from 1996 to 2012.
作者信息
Zuliani F, Prodi A, Fortina A B, Corradin M T, Bovenzi M, Filon F Larese
机构信息
Clinical Unit of Occupational Medicine, University of Trieste, Trieste, Italy.
Dermatology Unit, Department of Paediatrics, University of Padua, Padua, Italy.
出版信息
J Eur Acad Dermatol Venereol. 2017 May;31(5):833-836. doi: 10.1111/jdv.13992. Epub 2016 Oct 25.
BACKGROUND
4,4'-Diaminodiphenylmethane (DDM) is an aromatic amine used as a hardener, insulator and anticorrosive. Exposure implies risk of being sensitized and developing contact dermatitis.
OBJECTIVE
The aim of this study was to determine the occurrence of contact sensitization to DDM among patients with contact dermatitis and the role of occupational exposure.
PATIENTS AND METHODS
From 1996 to 2012, 24 056 consecutive patients with suspected allergic contact dermatitis were patch tested in north-eastern Italy. Individual characteristics were collected through a standardized questionnaire in eight departments of dermatology and occupational medicine.
RESULTS
The overall prevalence of DDM sensitization was 2.5% (n = 599) with a decreasing trend in considered years. Trieste area had the higher prevalence of sensitization (3.2%). Mechanics and chemical industry workers had a significant higher risk of being sensitized to DDM.
CONCLUSION
DDM sensitization is decreasing in years and is associated with some occupational exposures.
背景
4,4'-二氨基二苯甲烷（DDM）是一种用作硬化剂、绝缘体和防腐剂的芳香胺。接触意味着有被致敏和发生接触性皮炎的风险。
目的
本研究的目的是确定接触性皮炎患者中对DDM接触致敏的发生率以及职业暴露的作用。
患者和方法
1996年至2012年，意大利东北部对24056例连续的疑似过敏性接触性皮炎患者进行了斑贴试验。通过标准化问卷在八个皮肤科和职业医学科室收集个体特征。
结果
DDM致敏的总体患病率为2.5%（n = 599），在所考虑的年份中有下降趋势。的里雅斯特地区致敏患病率较高（3.2%）。机械工人和化工行业工人对DDM致敏的风险显著更高。
结论
多年来DDM致敏率在下降，且与某些职业暴露有关。
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