Gailhofer G, Ludvan M
Universitätsklinik für Dermatologie und Venerologie, Graz Osterreich.
Derm Beruf Umwelt. 1989 Jan-Feb;37(1):16-22.
This study was undertaken to determine the significance of positive patch test reactions to 4,4'-diaminodiphenylmethane (DDM). Data of 202 DDM-positive patients concerning age, sex and profession, type, localisation and duration of eczema and combined allergens were evaluated. The results obtained were compared by chi-square-test with those of 3397 consecutive, unselected contact dermatitis patients with negative reactions to DDM. The most conspicuous results were: 1. The positive patch test reaction to DDM is usually a marker for allergy to p-amino-compounds. 2. 39/202 patients showed isolated positive test reactions to DDM. The source of the allergen remained unclear. 3. Workers in chemical laboratories seem to have an increased risk for acquiring DDM-allergy. 4. The clinical relevance of DDM-allergy could only be proven in a few patients.
本研究旨在确定对4,4'-二氨基二苯甲烷（DDM）斑贴试验阳性反应的意义。评估了202例DDM阳性患者的年龄、性别、职业、湿疹类型、部位、病程及合并过敏原等数据。将所得结果与3397例连续的、未经挑选的对DDM反应阴性的接触性皮炎患者的结果进行卡方检验比较。最显著的结果如下：1. 对DDM的斑贴试验阳性反应通常是对对氨基化合物过敏的标志。2. 202例患者中有39例对DDM表现出孤立的阳性试验反应。过敏原来源不明。3. 化学实验室工作人员患DDM过敏的风险似乎增加。4. 仅在少数患者中证实了DDM过敏的临床相关性。
