Chubu University Graduate School of Life and Health Sciences, Aichi, Japan.
Department of Sleep Medicine, Nagoya University Graduate School of Medicine, Aichi, Japan.
Psychiatry Clin Neurosci. 2017 Jan;71(1):44-51. doi: 10.1111/pcn.12464. Epub 2016 Dec 11.
Short sleep duration is a risk factor for cardiovascular diseases. Cerebral blood flow and its regulation are affected by pathological conditions commonly observed in the elderly population, such as dementia, atherosclerosis, diabetes mellitus (DM), stroke, and hypertension. The purpose of this study was to examine the influence of sleep duration on cortical oxygenated hemoglobin (OxyHb) using near-infrared spectroscopy (NIRS).
Seventy-three individuals (age, 70.1 ± 3.9 years, 51 men and 22 women) participated in this study. Cortical OxyHb levels were measured with NIRS. We evaluated age, body mass index (BMI), smoking status, alcohol intake, sleep duration, hypertension, DM, and hyperlipidemia using a questionnaire. Blood pressure was measured using plethysmography.
Peak OxyHb and area under the NIRS curve significantly decreased in participants with sleep duration <7 h compared with those with sleep duration ≥7 h (0.136 ± 0.212 mM·mm vs 0.378 ± 0.342 mM·mm, P = 0.001; 112.0 ± 243.6 vs 331.7 ± 428.7, P = 0.012, respectively). Sleep duration was significantly correlated with peak OxyHb level and area under the NIRS curve (r = 0.378, P = 0.001; r = 0.285, P = 0.015, respectively). Multiple regression analysis, including age, BMI, sex, smoking status, alcohol intake, sleep duration, hypertension, DM, and hyperlipidemia revealed that sleep duration was the only significant independent factor associated with peak OxyHb and area under the NIRS curve (β = 0.343, P = 0.004; β = 0.244, P = 0.049, respectively), and smoking status was independently correlated with time to the peak OxyHb (β = -0.319, P = 0.009).
Sleep duration may be an important factor that influences cortical oxygenation in the elderly population.
睡眠时长过短是心血管疾病的一个风险因素。脑血流及其调节会受到一些常见于老年人群中的病理情况的影响，如痴呆、动脉粥样硬化、糖尿病（DM）、中风和高血压。本研究旨在通过近红外光谱（NIRS）检查睡眠时长对皮质氧合血红蛋白（OxyHb）的影响。
73 名参与者（年龄 70.1±3.9 岁，男性 51 名，女性 22 名）参与了这项研究。使用 NIRS 测量皮质 OxyHb 水平。我们通过问卷调查评估了年龄、体重指数（BMI）、吸烟状况、饮酒量、睡眠时长、高血压、DM 和高血脂。使用体积描记法测量血压。
与睡眠时长≥7 小时的参与者相比，睡眠时长＜7 小时的参与者的 OxyHb 峰值和 NIRS 曲线下面积显著降低（0.136±0.212mM·mm 比 0.378±0.342mM·mm，P=0.001；112.0±243.6 比 331.7±428.7，P=0.012）。睡眠时长与 OxyHb 峰值和 NIRS 曲线下面积呈显著相关（r=0.378，P=0.001；r=0.285，P=0.015）。包含年龄、BMI、性别、吸烟状况、饮酒量、睡眠时长、高血压、DM 和高血脂的多元回归分析表明，睡眠时长是与 OxyHb 峰值和 NIRS 曲线下面积相关的唯一显著独立因素（β=0.343，P=0.004；β=0.244，P=0.049），而吸烟状况与 OxyHb 峰值时间呈独立相关（β=-0.319，P=0.009）。
睡眠时长可能是影响老年人群皮质氧合的一个重要因素。
