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[Management of Adult Community-acquired Pneumonia and Prevention - Update 2016].[成人社区获得性肺炎的管理与预防——2016年更新]
Pneumologie. 2016 Mar;70(3):151-200. doi: 10.1055/s-0042-101873. Epub 2016 Feb 29.
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Evidence of non-linearity in the association of glycemic control with influenza/pneumonia mortality: a study of 19 000 adults from the US general population.血糖控制与流感/肺炎死亡率之间关联的非线性证据:一项对19000名美国普通成年人的研究。
Diabetes Metab Res Rev. 2016 Jan;32(1):111-20. doi: 10.1002/dmrr.2681. Epub 2015 Aug 20.
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Ten-Year Mortality after Community-acquired Pneumonia. A Prospective Cohort.社区获得性肺炎 10 年后的死亡率。一项前瞻性队列研究。
Am J Respir Crit Care Med. 2015 Sep 1;192(5):597-604. doi: 10.1164/rccm.201501-0140OC.
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Community-acquired pneumonia as medical emergency: predictors of early deterioration.社区获得性肺炎作为急症:早期恶化的预测因素。
Thorax. 2015 Jun;70(6):551-8. doi: 10.1136/thoraxjnl-2014-206744. Epub 2015 Mar 17.
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Pneumonia severity, comorbidity and 1-year mortality in predominantly older adults with community-acquired pneumonia: a cohort study.以老年人为主的社区获得性肺炎患者的肺炎严重程度、合并症及1年死亡率:一项队列研究
BMC Infect Dis. 2015 Jan 8;15:2. doi: 10.1186/s12879-014-0730-x.
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The prognostic significance of respiratory rate in patients with pneumonia: a retrospective analysis of data from 705,928 hospitalized patients in Germany from 2010-2012.呼吸率对肺炎患者预后的意义:2010-2012 年德国 705928 例住院患者数据的回顾性分析。
Dtsch Arztebl Int. 2014 Jul 21;111(29-30):503-8, i-v. doi: 10.3238/arztebl.2014.0503.
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Epidemiology and long-term clinical and biologic risk factors for pneumonia in community-dwelling older Americans: analysis of three cohorts.美国社区居住的老年人肺炎的流行病学和长期临床及生物学危险因素:三个队列的分析。
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Chronic heart failure and risk of hospitalization with pneumonia: a population-based study.慢性心力衰竭与肺炎住院风险:一项基于人群的研究。
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Strong associations of 25-hydroxyvitamin D concentrations with all-cause, cardiovascular, cancer, and respiratory disease mortality in a large cohort study.在一项大型队列研究中,25-羟维生素 D 浓度与全因、心血管、癌症和呼吸道疾病死亡率之间存在强烈关联。
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Proinflammatory cytokines, adiponectin, and increased risk of primary cardiovascular events in diabetic patients with or without renal dysfunction: results from the ESTHER study.在有或无肾功能障碍的糖尿病患者中,促炎细胞因子、脂联素与主要心血管事件风险增加相关:来自 ESTHER 研究的结果。
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非机构化老年人群中的肺炎

Pneumonia in the Noninstitutionalized Older Population.

作者信息

Breitling Lutz P, Saum Kai-Uwe, Schöttker Ben, Holleczek Bernd, Herth Felix J, Brenner Hermann

机构信息

Division of Clinical Epidemiology and Aging Research and Division of Preventive Oncology, German Cancer Research Center (DKFZ), Heidelberg, Pneumology and Respiratory Critical Care Medicine, Thorax Clinic at Heidelberg University Hospital:, Heidelberg, Network Aging Research (NAR), University of Heidelberg, Heidelberg, Saarland Cancer Registry, Saarbrücken, Translational Lung Research Center, Universität Heidelberg, Heidelberg.

出版信息

Dtsch Arztebl Int. 2016 Sep 16;113(37):607-614. doi: 10.3238/arztebl.2016.0607.

DOI:10.3238/arztebl.2016.0607
PMID:27697144
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5290257/
Abstract

BACKGROUND

Pneumonia is a common and potentially serious disease, with an incidence of ca. 300 per 100 000 persons per year. Until now, there have been only a few population-based studies of risk factors for pneumonia.

METHODS

From 2000 to 2002, nearly 10 000 persons aged 50 to 75 were recruited into the prospective ESTHER cohort study while visiting their family physician for a check-up. The mean duration of follow-up was 10.6 years. Data on newly diagnosed pneumonia were acquired from the participants and their physicians by means of standardized questionnaires. Potential associations with various predictors were studied in survival-time regression models.

RESULTS

435 participants had pneumonia at least once during follow-up. The cumulative 10-year-incidence was 4.5% (95% confidence interval [4.0; 4.9]). Multiple regression revealed that age (relative risk [RR]: 1.43 [1.22; 1.67] per 10 years), current cigarette smoking (RR: 1.56 [1.19; 2.05], compared with never having smoked), and known congestive heart failure (RR: 1.65 [1.24; 2.20]) were independently associated with an elevated risk of pneumonia. The risk was insignificantly elevated in persons with diabetes mellitus (RR: 1.29 [0.98; 1.68]). Alcohol consumption, obesity, stroke, and cancer were not associated with an elevated risk of pneumonia in age- and sex-adjusted analyses.

CONCLUSION

Pneumonia plays an important role in the medical care of non-institutionalized older people. With the aid of the predictors identified in this study, primary care physicians can identify patients at risk, smokers can gain additional motivation to quit, treatment compliance can be increased, and patients may become more willing to be vaccinated as recommended in the current guidelines.

摘要

背景

肺炎是一种常见且可能严重的疾病,每年发病率约为每10万人中有300例。到目前为止,基于人群的肺炎危险因素研究仅有少数几项。

方法

2000年至2002年期间,近10000名年龄在50至75岁的人在拜访家庭医生进行体检时被纳入前瞻性ESTHER队列研究。平均随访时间为10.6年。通过标准化问卷从参与者及其医生处获取新诊断肺炎的数据。在生存时间回归模型中研究了与各种预测因素的潜在关联。

结果

435名参与者在随访期间至少患过一次肺炎。累积10年发病率为4.5%(95%置信区间[4.0;4.9])。多元回归显示,年龄(相对风险[RR]:每10年1.43[1.22;1.67])、当前吸烟(RR:1.56[1.19;2.05],与从不吸烟相比)以及已知的充血性心力衰竭(RR:1.65[1.24;2.20])与肺炎风险升高独立相关。糖尿病患者的风险略有升高(RR:1.29[0.98;1.68])。在年龄和性别调整分析中,饮酒、肥胖、中风和癌症与肺炎风险升高无关。

结论

肺炎在非机构化老年人的医疗保健中起着重要作用。借助本研究确定的预测因素,初级保健医生可以识别有风险的患者,吸烟者可以获得更多戒烟动力,提高治疗依从性,患者可能更愿意按照当前指南的建议接种疫苗。