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非机构化老年人群中的肺炎

Pneumonia in the Noninstitutionalized Older Population.

作者信息

Breitling Lutz P, Saum Kai-Uwe, Schöttker Ben, Holleczek Bernd, Herth Felix J, Brenner Hermann

机构信息

Division of Clinical Epidemiology and Aging Research and Division of Preventive Oncology, German Cancer Research Center (DKFZ), Heidelberg, Pneumology and Respiratory Critical Care Medicine, Thorax Clinic at Heidelberg University Hospital:, Heidelberg, Network Aging Research (NAR), University of Heidelberg, Heidelberg, Saarland Cancer Registry, Saarbrücken, Translational Lung Research Center, Universität Heidelberg, Heidelberg.

出版信息

Dtsch Arztebl Int. 2016 Sep 16;113(37):607-614. doi: 10.3238/arztebl.2016.0607.

Abstract

BACKGROUND

Pneumonia is a common and potentially serious disease, with an incidence of ca. 300 per 100 000 persons per year. Until now, there have been only a few population-based studies of risk factors for pneumonia.

METHODS

From 2000 to 2002, nearly 10 000 persons aged 50 to 75 were recruited into the prospective ESTHER cohort study while visiting their family physician for a check-up. The mean duration of follow-up was 10.6 years. Data on newly diagnosed pneumonia were acquired from the participants and their physicians by means of standardized questionnaires. Potential associations with various predictors were studied in survival-time regression models.

RESULTS

435 participants had pneumonia at least once during follow-up. The cumulative 10-year-incidence was 4.5% (95% confidence interval [4.0; 4.9]). Multiple regression revealed that age (relative risk [RR]: 1.43 [1.22; 1.67] per 10 years), current cigarette smoking (RR: 1.56 [1.19; 2.05], compared with never having smoked), and known congestive heart failure (RR: 1.65 [1.24; 2.20]) were independently associated with an elevated risk of pneumonia. The risk was insignificantly elevated in persons with diabetes mellitus (RR: 1.29 [0.98; 1.68]). Alcohol consumption, obesity, stroke, and cancer were not associated with an elevated risk of pneumonia in age- and sex-adjusted analyses.

CONCLUSION

Pneumonia plays an important role in the medical care of non-institutionalized older people. With the aid of the predictors identified in this study, primary care physicians can identify patients at risk, smokers can gain additional motivation to quit, treatment compliance can be increased, and patients may become more willing to be vaccinated as recommended in the current guidelines.

摘要

背景

肺炎是一种常见且可能严重的疾病,每年发病率约为每10万人中有300例。到目前为止,基于人群的肺炎危险因素研究仅有少数几项。

方法

2000年至2002年期间,近10000名年龄在50至75岁的人在拜访家庭医生进行体检时被纳入前瞻性ESTHER队列研究。平均随访时间为10.6年。通过标准化问卷从参与者及其医生处获取新诊断肺炎的数据。在生存时间回归模型中研究了与各种预测因素的潜在关联。

结果

435名参与者在随访期间至少患过一次肺炎。累积10年发病率为4.5%(95%置信区间[4.0;4.9])。多元回归显示,年龄(相对风险[RR]:每10年1.43[1.22;1.67])、当前吸烟(RR:1.56[1.19;2.05],与从不吸烟相比)以及已知的充血性心力衰竭(RR:1.65[1.24;2.20])与肺炎风险升高独立相关。糖尿病患者的风险略有升高(RR:1.29[0.98;1.68])。在年龄和性别调整分析中,饮酒、肥胖、中风和癌症与肺炎风险升高无关。

结论

肺炎在非机构化老年人的医疗保健中起着重要作用。借助本研究确定的预测因素,初级保健医生可以识别有风险的患者,吸烟者可以获得更多戒烟动力,提高治疗依从性,患者可能更愿意按照当前指南的建议接种疫苗。

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