Yuen T, Sun L, Liu P, Blair H C, New M, Zallone A, Zaidi M
The Mount Sinai Bone Program, Department of Medicine, and Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
Departments of Pathology and of Cell Biology, University of Pittsburgh School of Medicine and the Pittsburgh VA Medical Center, Pittsburgh, PA, United States.
Prog Mol Biol Transl Sci. 2016;143:175-185. doi: 10.1016/bs.pmbts.2016.08.004. Epub 2016 Sep 7.
The long-held belief that pituitary hormones act solely on master targets was first questioned when we documented G protein-coupled receptors for thyroid-stimulating hormone, follicle-stimulating hormone, adrenocorticotrophic hormone, oxytocin, and vasopressin on bone cells. These evolutionarily conserved hormones and their receptors are known to have primitive roles, and exist in invertebrate species as far down as coelenterates. It is not surprising therefore that each such hormone has multiple hitherto unrecognized functions in mammalian integrative physiology, and hence, becomes a potential target for therapeutic intervention. Here we discuss the skeletal actions of pituitary hormones.
当我们在骨细胞上发现促甲状腺激素、促卵泡激素、促肾上腺皮质激素、催产素和血管加压素的G蛋白偶联受体时，长期以来认为垂体激素仅作用于主要靶标的观点首次受到质疑。这些在进化上保守的激素及其受体具有原始作用，并且存在于低至腔肠动物的无脊椎动物物种中。因此，毫不奇怪，每种此类激素在哺乳动物整合生理学中都具有多种迄今未被认识的功能，因此成为治疗干预的潜在靶点。在这里，我们讨论垂体激素的骨骼作用。
