Kumar T Rajendra
Edgar L. and Patricia M. Makowski Endowed Professor, Department of Obstetrics & Gynecology, University of Colorado Denver-Anschutz Medical Campus, Aurora, CO, United States.
Prog Mol Biol Transl Sci. 2016;143:49-84. doi: 10.1016/bs.pmbts.2016.08.006. Epub 2016 Sep 20.
Gonadotropins play fundamental roles in reproduction. More than 30years ago, Cga transgenic mice were generated, and more than 20years ago, the phenotypes of Cga null mice were reported. Since then, numerous mouse strains have been generated and characterized to address several questions in reproductive biology involving gonadotropin synthesis, secretion, and action. More recently, extragonadal expression, and in some cases, functions of gonadotropins in nongonadal tissues have been identified. Several genomic and proteomic approaches including novel mouse genome editing tools are available now. It is anticipated that these and other emerging technologies will be useful to build an integrated network of gonadotropin signaling pathways in various tissues. Undoubtedly, research on gonadotropins will continue to provide new knowledge and allow us transcend from benchside to the bedside.
促性腺激素在生殖过程中发挥着重要作用。30多年前，人们培育出了Cga转基因小鼠，20多年前，有报道称Cga基因敲除小鼠的表型。从那时起，人们培育并鉴定了许多小鼠品系，以解决生殖生物学中涉及促性腺激素合成、分泌和作用的几个问题。最近，已确定了促性腺激素在性腺外组织中的表达，在某些情况下还包括其功能。现在有几种基因组和蛋白质组学方法，包括新型小鼠基因组编辑工具。预计这些以及其他新兴技术将有助于构建各种组织中促性腺激素信号通路的综合网络。毫无疑问，对促性腺激素的研究将继续提供新知识，并使我们从实验室走向临床。
