Leon Lydia J, Solanky Nita, Stalman Susanne E, Demetriou Charalambos, Abu-Amero Sayeda, Stanier Philip, Regan Lesley, Moore Gudrun E
UCL Institute of Child Health, 30 Guilford Street, London WC1N 1EH, United Kingdom.
UCL Institute of Child Health, 30 Guilford Street, London WC1N 1EH, United Kingdom.
Placenta. 2016 Oct;46:31-37. doi: 10.1016/j.placenta.2016.08.085. Epub 2016 Aug 24.
About 20% of pregnancies are affected by some form of complication. Research has shown that anomalies in implantation, development, and growth of the fetus; ineffective nutrient exchange between mother and fetus due to placental dysfunction; and maternal problems such as hypertension or infection during pregnancy can all lead to adverse pregnancy outcomes. However, the molecular aetiology of such events remains poorly understood. Fetal growth restriction (FGR), recurrent miscarriage (RM), preterm birth (PTB), and pre-eclampsia (PE) are the most common pregnancy complications encountered in the UK and these outcomes can result in an array of morbidities in both mother and baby, and in the most severe cases in mortality. We need to know more about normal pregnancy and where the important triggers are for failure. This prompted us to collect a large set of biological samples with matching clinical data from over 2500 normal and abnormal pregnancies, for use in research into these conditions. This paper outlines the nature of these sample sets and their availability to academia and industry, with the intention that their widespread use in research will make significant contributions to the improvement of maternal and fetal health worldwide (http://www.ucl.ac.uk/tapb/sample-and-data-collections-at-ucl/biobanks-ucl/baby-biobank).
约20%的妊娠会受到某种形式并发症的影响。研究表明，胎儿着床、发育和生长异常；胎盘功能障碍导致母体与胎儿之间营养物质交换无效；以及孕期母体问题，如高血压或感染，都可能导致不良妊娠结局。然而，此类事件的分子病因仍知之甚少。胎儿生长受限（FGR）、复发性流产（RM）、早产（PTB）和子痫前期（PE）是英国最常见的妊娠并发症，这些结局可能导致母婴出现一系列疾病，在最严重的情况下会导致死亡。我们需要更多地了解正常妊娠以及导致妊娠失败的重要触发因素。这促使我们收集了来自2500多例正常和异常妊娠的大量生物样本及匹配的临床数据，用于对这些情况的研究。本文概述了这些样本集的性质以及它们对学术界和产业界的可获取性，旨在它们在研究中的广泛应用将为全球改善母婴健康做出重大贡献（http://www.ucl.ac.uk/tapb/sample-and-data-collections-at-ucl/biobanks-ucl/baby-biobank）。
