Habtemariam Solomon
Pharmacognosy Research Laboratories, University of Greenwich, Chatham-Maritime, Kent ME4 4TB, UK; Herbal Analysis Services, UK.
Pharmacol Res. 2016 Nov;113(Pt A):592-599. doi: 10.1016/j.phrs.2016.09.041. Epub 2016 Sep 30.
Berberine is the principal component of many popular medicinal plants (e.g. the genus Berberis, Coptis and Hydrastis among others) with a history of thousands of years of usage in traditional medicine. The numerous pharmacological activities of berberine reported in the last two decades have been attracting high level interests both within the scientific community, clinicians and the public at large. Despite enormous amount of efforts have been placed to show its therapeutic value for inflammatory bowel diseases (IBD), however, comprehensive up-to-date review article in this field is not yet available. In this communication, literature data from in vitro and in vivo experiments were scrutinised and concisely presented to demonstrate its anti-IBD potential. Beyond the known general antioxidant and anti-inflammatory effects of berberine, IBD-specific effects including gut epithelial barrier pathology, T cells as emerging targets, antinociceptive and other effects are discussed.
黄连素是许多常见药用植物（如小檗属、黄连属和白毛茛属等）的主要成分，在传统医学中已有数千年的使用历史。过去二十年来报道的黄连素的众多药理活性引起了科学界、临床医生和广大公众的高度关注。尽管已经付出了巨大努力来证明其对炎症性肠病（IBD）的治疗价值，然而，该领域全面的最新综述文章尚未问世。在本通讯中，对来自体外和体内实验的文献数据进行了审查并简要呈现，以证明其抗IBD潜力。除了已知的黄连素的一般抗氧化和抗炎作用外，还讨论了IBD特异性作用，包括肠道上皮屏障病理学、作为新兴靶点的T细胞、抗伤害感受作用及其他作用。
