High incidence of activating STAT5B mutations in CD4-positive T-cell large granular lymphocyte leukemia.
作者信息
Andersson Emma I, Tanahashi Takahiro, Sekiguchi Nodoka, Gasparini Vanessa Rebecca, Bortoluzzi Sabrina, Kawakami Toru, Matsuda Kazuyuki, Mitsui Takeki, Eldfors Samuli, Bortoluzzi Stefania, Coppe Alessandro, Binatti Andrea, Lagström Sonja, Ellonen Pekka, Fukushima Noriyasu, Nishina Sayaka, Senoo Noriko, Sakai Hitoshi, Nakazawa Hideyuki, Kwong Yok-Lam, Loughran Thomas P, Maciejewski Jaroslaw P, Mustjoki Satu, Ishida Fumihiro
机构信息
Hematology Research Unit Helsinki, Department of Clinical Chemistry and Hematology, University of Helsinki, Helsinki, Finland.
Department of Clinical Laboratory Investigation, Graduate School of Medicine, Shinshu University, Matsumoto, Japan.
出版信息
Blood. 2016 Nov 17;128(20):2465-2468. doi: 10.1182/blood-2016-06-724856. Epub 2016 Oct 3.
Abstract
摘要
相似文献
1
High incidence of activating STAT5B mutations in CD4-positive T-cell large granular lymphocyte leukemia.
Blood. 2016 Nov 17;128(20):2465-2468. doi: 10.1182/blood-2016-06-724856. Epub 2016 Oct 3.
2
T cell large granular lymphocyte leukemia and chronic NK lymphocytosis.
Best Pract Res Clin Haematol. 2019 Sep;32(3):207-216. doi: 10.1016/j.beha.2019.06.006. Epub 2019 Jun 22.
3
STAT5b in LGL leukemia--a novel therapeutic target?
Oncotarget. 2013 Jun;4(6):808-9. doi: 10.18632/oncotarget.1035.
4
Uncovering the pathogenesis of large granular lymphocytic leukemia-novel STAT3 and STAT5b mutations.
Ann Med. 2014 May;46(3):114-22. doi: 10.3109/07853890.2014.882105. Epub 2014 Feb 11.
5
T-cell large granular lymphocytic (LGL) leukemia consists of CD4/CD8 and CD4/CD8 LGL populations in association with immune thrombocytopenia, autoimmune neutropenia, and monoclonal B-cell lymphocytosis.
J Clin Exp Hematop. 2019;59(4):202-206. doi: 10.3960/jslrt.19030.
6
STAT3 mutations are not sufficient to induce large granular lymphocytic leukaemia in mice.
Br J Haematol. 2018 Mar;180(6):911-915. doi: 10.1111/bjh.14487. Epub 2016 Dec 26.
7
and mutations have unique distribution in T-cell large granular lymphocyte proliferations and advanced myeloid neoplasms.
Leuk Lymphoma. 2021 Jun;62(6):1506-1509. doi: 10.1080/10428194.2020.1869964. Epub 2021 Jan 7.
8
Identification of novel STAT5B mutations and characterization of TCRβ signatures in CD4+ T-cell large granular lymphocyte leukemia.
Blood Cancer J. 2022 Feb 24;12(2):31. doi: 10.1038/s41408-022-00630-8.
9
Discovery of somatic STAT5b mutations in large granular lymphocytic leukemia.
Blood. 2013 May 30;121(22):4541-50. doi: 10.1182/blood-2012-12-474577. Epub 2013 Apr 17.
10
Somatic mutations in Felty syndrome: an implication for a common pathogenesis with large granular lymphocyte leukemia.
Haematologica. 2018 Feb;103(2):304-312. doi: 10.3324/haematol.2017.175729. Epub 2017 Dec 7.
引用本文的文献
1
Transcriptomic landscape of CD8+ and CD4 + T-LGL leukemia revealed the distinct impact of STAT3 and STAT5B activating mutations.
Leukemia. 2025 Jul 28. doi: 10.1038/s41375-025-02708-1.
2
Crescentic glomerulonephritis associated with NK-large granular lymphocytic leukemia: A case report.
Medicine (Baltimore). 2025 Jul 4;104(27):e43294. doi: 10.1097/MD.0000000000043294.
3
STAT5B leukemic mutations, altering SH2 tyrosine 665, have opposing impacts on immune gene programs.
Life Sci Alliance. 2025 Apr 14;8(7). doi: 10.26508/lsa.202503222. Print 2025 Jul.
4
STAT5B leukemic mutations, altering SH2 tyrosine 665, have opposing impacts on immune gene programs.
bioRxiv. 2024 Dec 22:2024.12.20.629685. doi: 10.1101/2024.12.20.629685.
5
HSP and CD279 gene expression as candidate biomarkers in symptomatic LGLL patients.
Discov Oncol. 2024 Dec 18;15(1):764. doi: 10.1007/s12672-024-01657-y.
6
mutations in large granular lymphocytic leukemia.
Haematologica. 2024 Sep 1;109(9):3067-3070. doi: 10.3324/haematol.2024.285404.
7
Hyperactive STAT5 hijacks T cell receptor signaling and drives immature T cell acute lymphoblastic leukemia.
J Clin Invest. 2024 Apr 15;134(8):e168536. doi: 10.1172/JCI168536.
8
Large Granular Lymphocytic Leukemia: Clinical Features, Molecular Pathogenesis, Diagnosis and Treatment.
Cancers (Basel). 2024 Mar 27;16(7):1307. doi: 10.3390/cancers16071307.
9
Unveiling myeloid transformation: T-LGLL with eosinophilia masking myeloid-associated STAT5B mutation culminating in AML.
Br J Haematol. 2024 Jun;204(6):2487-2491. doi: 10.1111/bjh.19421. Epub 2024 Mar 20.
10
A lineage-specific STAT5BN642H mouse model to study NK-cell leukemia.
Blood. 2024 Jun 13;143(24):2474-2489. doi: 10.1182/blood.2023022655.
本文引用的文献
1
JAK-STAT and G-protein-coupled receptor signaling pathways are frequently altered in epitheliotropic intestinal T-cell lymphoma.
Leukemia. 2016 Jun;30(6):1311-9. doi: 10.1038/leu.2016.13. Epub 2016 Feb 8.
2
Activating mutations of STAT5B and STAT3 in lymphomas derived from γδ-T or NK cells.
Nat Commun. 2015 Jan 14;6:6025. doi: 10.1038/ncomms7025.
3
The analysis of clonal diversity and therapy responses using STAT3 mutations as a molecular marker in large granular lymphocytic leukemia.
Haematologica. 2015 Jan;100(1):91-9. doi: 10.3324/haematol.2014.113142. Epub 2014 Oct 3.
4
The activating STAT5B N642H mutation is a common abnormality in pediatric T-cell acute lymphoblastic leukemia and confers a higher risk of relapse.
Haematologica. 2014 Oct;99(10):e188-92. doi: 10.3324/haematol.2014.104992. Epub 2014 Jun 27.
5
Frequent STAT5B mutations in γδ hepatosplenic T-cell lymphomas.
Leukemia. 2014 Nov;28(11):2244-8. doi: 10.1038/leu.2014.200. Epub 2014 Jun 20.
6
Integrated genomic sequencing reveals mutational landscape of T-cell prolymphocytic leukemia.
Blood. 2014 Aug 28;124(9):1460-72. doi: 10.1182/blood-2014-03-559542. Epub 2014 May 13.
7
Novel activating STAT5B mutations as putative drivers of T-cell acute lymphoblastic leukemia.
Leukemia. 2014 Aug;28(8):1738-42. doi: 10.1038/leu.2014.89. Epub 2014 Feb 27.
8
Identification of STAT5A and STAT5B target genes in human T cells.
PLoS One. 2014 Jan 30;9(1):e86790. doi: 10.1371/journal.pone.0086790. eCollection 2014.
9
Novel somatic mutations in large granular lymphocytic leukemia affecting the STAT-pathway and T-cell activation.
Blood Cancer J. 2013 Dec 6;3(12):e168. doi: 10.1038/bcj.2013.65.
10
Discovery of somatic STAT5b mutations in large granular lymphocytic leukemia.
Blood. 2013 May 30;121(22):4541-50. doi: 10.1182/blood-2012-12-474577. Epub 2013 Apr 17.
Zotero 插件