High incidence of activating STAT5B mutations in CD4-positive T-cell large granular lymphocyte leukemia.
作者信息
Andersson Emma I, Tanahashi Takahiro, Sekiguchi Nodoka, Gasparini Vanessa Rebecca, Bortoluzzi Sabrina, Kawakami Toru, Matsuda Kazuyuki, Mitsui Takeki, Eldfors Samuli, Bortoluzzi Stefania, Coppe Alessandro, Binatti Andrea, Lagström Sonja, Ellonen Pekka, Fukushima Noriyasu, Nishina Sayaka, Senoo Noriko, Sakai Hitoshi, Nakazawa Hideyuki, Kwong Yok-Lam, Loughran Thomas P, Maciejewski Jaroslaw P, Mustjoki Satu, Ishida Fumihiro
机构信息
Hematology Research Unit Helsinki, Department of Clinical Chemistry and Hematology, University of Helsinki, Helsinki, Finland.
Department of Clinical Laboratory Investigation, Graduate School of Medicine, Shinshu University, Matsumoto, Japan.
出版信息
Blood. 2016 Nov 17;128(20):2465-2468. doi: 10.1182/blood-2016-06-724856. Epub 2016 Oct 3.
Abstract
摘要
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Leukemia. 2016 Jun;30(6):1311-9. doi: 10.1038/leu.2016.13. Epub 2016 Feb 8.
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Activating mutations of STAT5B and STAT3 in lymphomas derived from γδ-T or NK cells.源自γδ-T细胞或NK细胞的淋巴瘤中STAT5B和STAT3的激活突变。
Nat Commun. 2015 Jan 14;6:6025. doi: 10.1038/ncomms7025.
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The analysis of clonal diversity and therapy responses using STAT3 mutations as a molecular marker in large granular lymphocytic leukemia.在大颗粒淋巴细胞白血病中使用STAT3突变作为分子标志物分析克隆多样性和治疗反应。
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The activating STAT5B N642H mutation is a common abnormality in pediatric T-cell acute lymphoblastic leukemia and confers a higher risk of relapse.激活型STAT5B N642H突变是儿童T细胞急性淋巴细胞白血病中的常见异常，会增加复发风险。
Haematologica. 2014 Oct;99(10):e188-92. doi: 10.3324/haematol.2014.104992. Epub 2014 Jun 27.
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Frequent STAT5B mutations in γδ hepatosplenic T-cell lymphomas.γδ肝脾T细胞淋巴瘤中频繁出现的STAT5B突变。
Leukemia. 2014 Nov;28(11):2244-8. doi: 10.1038/leu.2014.200. Epub 2014 Jun 20.
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Integrated genomic sequencing reveals mutational landscape of T-cell prolymphocytic leukemia.综合基因组测序揭示T细胞原淋巴细胞白血病的突变图谱。
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Novel activating STAT5B mutations as putative drivers of T-cell acute lymphoblastic leukemia.新型激活型STAT5B突变作为T细胞急性淋巴细胞白血病的潜在驱动因素
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Identification of STAT5A and STAT5B target genes in human T cells.人类T细胞中STAT5A和STAT5B靶基因的鉴定。
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Novel somatic mutations in large granular lymphocytic leukemia affecting the STAT-pathway and T-cell activation.大颗粒淋巴细胞白血病中影响 STAT 通路和 T 细胞激活的新型体细胞突变。
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Discovery of somatic STAT5b mutations in large granular lymphocytic leukemia.大颗粒淋巴细胞白血病中体细胞 STAT5b 突变的发现。
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