STAT3 mutations are not sufficient to induce large granular lymphocytic leukaemia in mice.
作者信息
Dutta Avik, Yan Dongqing, Hutchison Robert E, Mohi Golam
机构信息
Department of Pharmacology, SUNY Upstate Medical University, Syracuse, NY, USA.
Department of Pathology, SUNY Upstate Medical University, Syracuse, NY, USA.
出版信息
Br J Haematol. 2018 Mar;180(6):911-915. doi: 10.1111/bjh.14487. Epub 2016 Dec 26.
Abstract
摘要
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Revisiting STAT3 signalling in cancer: new and unexpected biological functions.重新审视 STAT3 信号通路在癌症中的作用：新的、意想不到的生物学功能。
Nat Rev Cancer. 2014 Nov;14(11):736-46. doi: 10.1038/nrc3818.
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The pathogenesis and treatment of large granular lymphocyte leukemia.大颗粒淋巴细胞白血病的发病机制与治疗
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Novel somatic mutations in large granular lymphocytic leukemia affecting the STAT-pathway and T-cell activation.大颗粒淋巴细胞白血病中影响 STAT 通路和 T 细胞激活的新型体细胞突变。
Blood Cancer J. 2013 Dec 6;3(12):e168. doi: 10.1038/bcj.2013.65.
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STAT3 mutations identified in human hematologic neoplasms induce myeloid malignancies in a mouse bone marrow transplantation model.在人类血液系统肿瘤中鉴定出的 STAT3 突变在小鼠骨髓移植模型中诱导髓系恶性肿瘤。
Haematologica. 2013 Nov;98(11):1748-52. doi: 10.3324/haematol.2013.085068. Epub 2013 Jul 19.
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Discovery of somatic STAT5b mutations in large granular lymphocytic leukemia.大颗粒淋巴细胞白血病中体细胞 STAT5b 突变的发现。
Blood. 2013 May 30;121(22):4541-50. doi: 10.1182/blood-2012-12-474577. Epub 2013 Apr 17.
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Intrinsic and extrinsic mechanisms contribute to maintain the JAK/STAT pathway aberrantly activated in T-type large granular lymphocyte leukemia.内在和外在机制有助于维持 T 型大颗粒淋巴细胞白血病中 JAK/STAT 通路的异常激活。
Blood. 2013 May 9;121(19):3843-54, S1. doi: 10.1182/blood-2012-07-441378. Epub 2013 Mar 20.
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JAK/STAT signaling in hematological malignancies.JAK/STAT 信号通路在血液系统恶性肿瘤中的作用。
Oncogene. 2013 May 23;32(21):2601-13. doi: 10.1038/onc.2012.347. Epub 2012 Aug 6.
8
STAT3 mutations unify the pathogenesis of chronic lymphoproliferative disorders of NK cells and T-cell large granular lymphocyte leukemia.STAT3 突变使 NK 细胞慢性淋巴增殖性疾病和 T 细胞大颗粒淋巴细胞白血病的发病机制趋于统一。
Blood. 2012 Oct 11;120(15):3048-57. doi: 10.1182/blood-2012-06-435297. Epub 2012 Aug 2.
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Somatic STAT3 mutations in large granular lymphocytic leukemia.大颗粒淋巴细胞白血病中的体细胞 STAT3 突变。
N Engl J Med. 2012 May 17;366(20):1905-13. doi: 10.1056/NEJMoa1114885.
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