Huang Yu-Mei, Rasband Matthew N
Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030.
Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030
J Cell Biol. 2016 Oct 10;215(1):9-11. doi: 10.1083/jcb.201609084. Epub 2016 Oct 3.
What prevents the movement of membrane molecules between axonal and somatodendritic domains is unclear. In this issue, Albrecht et. al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201603108) demonstrate via high-speed single-particle tracking and superresolution microscopy that lipid-anchored molecules in the axon initial segment are confined to membrane domains separated by periodically spaced actin rings.
尚不清楚是什么阻止了膜分子在轴突和树突体区域之间移动。在本期中，阿尔布雷希特等人（2016年，《细胞生物学杂志》，http://dx.doi.org/10.1083/jcb.201603108）通过高速单粒子追踪和超分辨率显微镜证明，轴突起始段中的脂质锚定分子被限制在由周期性间隔的肌动蛋白环分隔的膜结构域中。
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