• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

痴呆风险降低研究的未来:障碍与解决方案。

The future of dementia risk reduction research: barriers and solutions.

机构信息

Alzheimer's Research UK, Granta Park, Cambridge CB21 6AD, UK.

出版信息

J Public Health (Oxf). 2017 Dec 1;39(4):e275-e281. doi: 10.1093/pubmed/fdw103.

DOI:10.1093/pubmed/fdw103
PMID:27698267
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5896599/
Abstract

BACKGROUND

We examine why dementia prevention and risk reduction are relatively underfunded and suggest potential remediation strategies. The paper is aimed at researchers, funders and policy-makers, both within dementia and also the wider health prevention field.

METHODS

A discussion-led workshop, attended by 58 academics, clinicians, funders and policy-makers.

RESULTS

The key barriers identified were the gaps in understanding the basic science of dementia; the complex interplay between individual risk factors; variations in study methodology; disincentives to collaboration; a lack of research capacity and leadership and the broader stigma of the condition. Recommendations were made to encourage strategic leadership, provide greater support for grant applications, promote collaboration and support randomized control trials for the research field.

CONCLUSION

Having identified the barriers, the key challenge is how to implement the potential solutions. This will require engagement with decision-makers within funding, policy and research to ensure that action takes place.

摘要

背景

我们探讨了为何预防痴呆症和降低风险的相关措施资金投入相对较少,并提出了一些潜在的补救策略。本文面向痴呆症领域以及更广泛的健康预防领域的研究人员、资助者和政策制定者。

方法

一场由 58 名学者、临床医生、资助者和政策制定者参加的以讨论为主导的研讨会。

结果

确定的主要障碍包括对痴呆症基础科学理解的差距;个体风险因素之间的复杂相互作用;研究方法的差异;合作的激励不足;研究能力和领导力的缺乏以及该病症的普遍污名化。建议鼓励战略领导力,为资助申请提供更多支持,促进合作,并为研究领域提供随机对照试验。

结论

在确定了障碍之后,关键的挑战是如何实施潜在的解决方案。这将需要与资金、政策和研究领域的决策者进行接触,以确保采取行动。

相似文献

1
The future of dementia risk reduction research: barriers and solutions.痴呆风险降低研究的未来:障碍与解决方案。
J Public Health (Oxf). 2017 Dec 1;39(4):e275-e281. doi: 10.1093/pubmed/fdw103.
2
The future of Cochrane Neonatal.考克兰新生儿协作网的未来。
Early Hum Dev. 2020 Nov;150:105191. doi: 10.1016/j.earlhumdev.2020.105191. Epub 2020 Sep 12.
3
A research roadmap for complementary and alternative medicine - what we need to know by 2020.补充和替代医学研究路线图——到2020年我们需要了解的内容。
Forsch Komplementmed. 2014;21(2):e1-16. doi: 10.1159/000360744. Epub 2014 Mar 24.
4
A roadmap to advance dementia research in prevention, diagnosis, intervention, and care by 2025.到 2025 年推进痴呆症预防、诊断、干预和护理研究的路线图。
Int J Geriatr Psychiatry. 2018 Jul;33(7):900-906. doi: 10.1002/gps.4868. Epub 2018 Feb 22.
5
Gaps and strategies in developing health research capacity: experience from the Nigeria Implementation Science Alliance.发展卫生研究能力方面的差距和策略:来自尼日利亚实施科学联盟的经验。
Health Res Policy Syst. 2018 Feb 12;16(1):10. doi: 10.1186/s12961-018-0289-x.
6
How policy can help develop and sustain workforce capacity in UK dementia research: insights from a career tracking analysis and stakeholder interviews.政策如何助力英国痴呆症研究领域培养并维持劳动力能力:来自职业追踪分析及利益相关者访谈的见解
BMJ Open. 2016 Aug 31;6(8):e012052. doi: 10.1136/bmjopen-2016-012052.
7
What would a population-level approach to dementia risk reduction look like, and how would it work?在人群层面上降低痴呆症风险的方法会是什么样子,它将如何运作?
Alzheimers Dement. 2023 Jul;19(7):3203-3209. doi: 10.1002/alz.12985. Epub 2023 Feb 15.
8
Dementia Prevention and Individual and Socioeconomic Barriers: Avoiding "Lifestyle" Stigma.痴呆症预防与个体和社会经济障碍:避免“生活方式”污名化。
Gerontologist. 2024 May 1;64(5). doi: 10.1093/geront/gnad130.
9
Patient-Oriented Research Competencies in Health (PORCH) for patients, healthcare providers, decision-makers and researchers: protocol of a scoping review.面向患者、医疗保健提供者、决策者和研究人员的健康患者导向研究能力(PORCH):系统评价方案。
Syst Rev. 2018 Jul 19;7(1):101. doi: 10.1186/s13643-018-0762-1.
10
State of Research Quality and Knowledge Transfer and Translation and Capacity Strengthening Strategies for Sound Health Policy Decision-Making in Palestine.巴勒斯坦健康决策的研究质量、知识转移和翻译状况及能力强化策略
Int J Public Health. 2021 Aug 2;66:620425. doi: 10.3389/ijph.2021.620425. eCollection 2021.

引用本文的文献

1
The pathogenesis of cerebral small vessel disease and vascular cognitive impairment.脑小血管病与血管性认知障碍的发病机制。
Physiol Rev. 2025 Jul 1;105(3):1075-1171. doi: 10.1152/physrev.00028.2024. Epub 2025 Feb 18.
2
Effects of Mindfulness-Based Interventions (MBIs) in Patients with Early-Stage Alzheimer's Disease: A Pilot Study.基于正念的干预措施对早期阿尔茨海默病患者的影响:一项试点研究。
Brain Sci. 2023 Mar 13;13(3):484. doi: 10.3390/brainsci13030484.
3
Brain atrophy in middle age using magnetic resonance imaging scans from Japan's health screening programme.利用日本健康筛查项目的磁共振成像扫描研究中年人的脑萎缩情况。
Brain Commun. 2022 Aug 22;4(4):fcac211. doi: 10.1093/braincomms/fcac211. eCollection 2022.
4
The Resilience Index: A Quantifiable Measure of Brain Health and Risk of Cognitive Impairment and Dementia.韧性指数:大脑健康和认知障碍及痴呆风险的可量化指标。
J Alzheimers Dis. 2021;84(4):1729-1746. doi: 10.3233/JAD-215077.
5
Rates, risks and routes to reduce vascular dementia (R4vad), a UK-wide multicentre prospective observational cohort study of cognition after stroke: Protocol.降低血管性痴呆的发生率、风险及途径(R4vad),一项全英国范围内关于卒中后认知的多中心前瞻性观察队列研究:方案
Eur Stroke J. 2021 Mar;6(1):89-101. doi: 10.1177/2396987320953312. Epub 2020 Oct 11.
6
The Cognitive & Leisure Activity Scale (CLAS): A new measure to quantify cognitive activities in older adults with and without cognitive impairment.认知与休闲活动量表(CLAS):一种用于量化有认知障碍和无认知障碍老年人认知活动的新测量方法。
Alzheimers Dement (N Y). 2021 Mar 31;7(1):e12134. doi: 10.1002/trc2.12134. eCollection 2021.
7
The Effect of Baseline Patient and Caregiver Mindfulness on Dementia Outcomes.基线患者和照护者正念对痴呆症结局的影响。
J Alzheimers Dis. 2021;79(3):1345-1367. doi: 10.3233/JAD-201292.
8
An Agenda for Addressing Multimorbidity and Racial and Ethnic Disparities in Alzheimer's Disease and Related Dementia.解决阿尔茨海默病及相关痴呆症中的多病共存和种族及民族差异问题的议程
Am J Alzheimers Dis Other Demen. 2020 Jan-Dec;35:1533317520960874. doi: 10.1177/1533317520960874.
9
Implementing dementia risk reduction in primary care: a preliminary conceptual model based on a scoping review of practitioners' views.在初级保健中实施痴呆症风险降低措施:基于对从业者观点的范围审查得出的初步概念模型
Prim Health Care Res Dev. 2019 Oct 23;20:e140. doi: 10.1017/S1463423619000744.
10
Midlife Psychological Well-Being and its Impact on Cognitive Functioning Later in Life: An Observational Study Using a Female British Birth Cohort.中年期心理幸福感及其对晚年认知功能的影响:利用英国女性出生队列的观察性研究。
J Alzheimers Dis. 2019;72(3):835-843. doi: 10.3233/JAD-190590.

本文引用的文献

1
A two decade dementia incidence comparison from the Cognitive Function and Ageing Studies I and II.来自认知功能与衰老研究I和II的二十年痴呆症发病率比较。
Nat Commun. 2016 Apr 19;7:11398. doi: 10.1038/ncomms11398.
2
A multimodal approach to dementia prevention: A report from the Cambridge Institute of Public Health.一种预防痴呆症的多模式方法:剑桥公共卫生研究所的报告。
Alzheimers Dement (N Y). 2015 Oct 1;1(3):151-156. doi: 10.1016/j.trci.2015.08.003. eCollection 2015 Nov.
3
MAPT STUDY: A MULTIDOMAIN APPROACH FOR PREVENTING ALZHEIMER'S DISEASE: DESIGN AND BASELINE DATA.微管相关蛋白tau(MAPT)研究:一种预防阿尔茨海默病的多领域方法:设计与基线数据
J Prev Alzheimers Dis. 2014 Jun;1(1):13-22.
4
Bridging the Translation Gap: From Dementia Risk Assessment to Advice on Risk Reduction.弥合翻译差距:从痴呆症风险评估到降低风险的建议。
J Prev Alzheimers Dis. 2015;2(3):189-198. doi: 10.14283/jpad.2015.75.
5
Prevention of sporadic Alzheimer's disease: lessons learned from clinical trials and future directions.预防散发性阿尔茨海默病:临床试验的经验教训和未来方向。
Lancet Neurol. 2015 Sep;14(9):926-944. doi: 10.1016/S1474-4422(15)00153-2. Epub 2015 Jul 23.
6
The potential for prevention of dementia across two decades: the prospective, population-based Rotterdam Study.二十年间预防痴呆症的潜力:基于人群的前瞻性鹿特丹研究
BMC Med. 2015 Jul 21;13:132. doi: 10.1186/s12916-015-0377-5.
7
Summary of the evidence on modifiable risk factors for cognitive decline and dementia: A population-based perspective.认知衰退和痴呆可调节风险因素的证据总结:基于人群的观点。
Alzheimers Dement. 2015 Jun;11(6):718-26. doi: 10.1016/j.jalz.2015.05.016. Epub 2015 Jun 1.
8
WHO takes up the baton on dementia.世界卫生组织接过了应对痴呆症的接力棒。
Lancet Neurol. 2015 May;14(5):455. doi: 10.1016/S1474-4422(15)00022-8. Epub 2015 Apr 12.
9
Dementia trials and dementia tribulations: methodological and analytical challenges in dementia research.痴呆症试验与痴呆症困境:痴呆症研究中的方法学与分析挑战
Alzheimers Res Ther. 2015 Mar 18;7(1):31. doi: 10.1186/s13195-015-0113-6. eCollection 2015.
10
A 2 year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (FINGER): a randomised controlled trial.一项针对高危老年人的饮食、运动、认知训练和血管风险监测的 2 年多领域干预措施,以预防认知能力下降(FINGER):一项随机对照试验。
Lancet. 2015 Jun 6;385(9984):2255-63. doi: 10.1016/S0140-6736(15)60461-5. Epub 2015 Mar 12.