Apaer Shadike, Tuxun Tuerhongjiang, Ma Hai-Zhang, Zhang Heng, Aierken Amina, Aini Abudusalamu, Li Yu-Peng, Lin Ren-Yong, Wen Hao
State Key Laboratory of Xinjiang Major Diseases Research and Xinjiang Key Laboratory of Echinococcosis, First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830054, P.R. China; Department of Liver and Laparoscopic Surgery, Digestive and Vascular Centre, First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830054, P.R. China.
State Key Laboratory of Xinjiang Major Diseases Research and Xinjiang Key Laboratory of Echinococcosis, First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830054, P.R. China.
Exp Ther Med. 2016 Oct;12(4):2359-2366. doi: 10.3892/etm.2016.3660. Epub 2016 Sep 5.
Parasites, which are a recently discovered yet ancient dweller in human hosts, remain a great public health burden in underdeveloped countries, despite preventative efforts. Rheumatoid arthritis is a predominantly cosmopolitan health problem with drastic morbidity rates, although encouraging progress has been achieved regarding treatment. However, although various types of methods and agents have been applied clinically, their broad usage has been limited by their adverse effects and/or high costs. Sustained efforts have been exerted on the 'hygiene hypothesis' since the 1870s. The immunosuppressive nature of parasitic infections may offer potential insight into therapeutic strategies for rheumatoid arthritis, in which the immune system is overactivated. An increasing number of published papers are focusing on the preventive and/or curative effect of various parasitic infection on rheumatoid arthritis from experimental studies to large-scale epidemiological studies and clinical trials. Therefore, the present review aimed to provide a general literature review on the possible beneficial role of parasitic infection on rheumatoid arthritis.
寄生虫是人类宿主体内一种最近才被发现但却古老的寄居者，尽管人们做出了预防努力，但在欠发达国家，寄生虫仍然是一个巨大的公共卫生负担。类风湿性关节炎是一个主要在全球范围内存在的健康问题，发病率极高，尽管在治疗方面已经取得了令人鼓舞的进展。然而，尽管临床上已经应用了各种类型的方法和药物，但其广泛应用受到了副作用和/或高成本的限制。自19世纪70年代以来，人们一直在持续努力研究“卫生假说”。寄生虫感染的免疫抑制特性可能为类风湿性关节炎的治疗策略提供潜在的见解，在类风湿性关节炎中免疫系统过度激活。越来越多已发表的论文从实验研究到大规模流行病学研究和临床试验，都在关注各种寄生虫感染对类风湿性关节炎的预防和/或治疗作用。因此，本综述旨在对寄生虫感染对类风湿性关节炎可能的有益作用进行一般性文献综述。
