上皮钠通道/退化素在肿瘤发生发展中的作用
ENaC/DEG in Tumor Development and Progression.
作者信息
Liu Cui, Zhu Li-Li, Xu Si-Guang, Ji Hong-Long, Li Xiu-Min
机构信息
School of Nursing, Xinxiang Medical University, Xinxiang 453003, Henan Province, P. R. China.
Institute of Lung and Molecular Therapy, Xinxiang Medical University, Xinxiang 453003, Henan Province, P. R. China.
出版信息
J Cancer. 2016 Sep 13;7(13):1888-1891. doi: 10.7150/jca.15693. eCollection 2016.
Abstract
The epithelial Na channel/degenerin (ENaC/DEG) superfamily, including the acid-sensing ion channels (ASICs), is characterized by a high degree of similarity in structure but highly diverse in physiological functions. These ion channels have been shown to be important in several physiological functions of normal epithelial cells, including salt homeostasis, fluid transportation and cell mobility. There is increasing evidence suggesting that ENaC/DEG channels are critically engaged in cancer cell biology, such as proliferation, migration, invasion and apoptosis, playing a role in tumor development and progression. In this review, we will discuss recent studies showing the role of ENaC and ASIC channels in epithelial cells and its relationship to the oncogenesis.
摘要
上皮钠通道/退化素（ENaC/DEG）超家族，包括酸敏感离子通道（ASICs），其特点是结构高度相似，但生理功能却高度多样。这些离子通道已被证明在正常上皮细胞的多种生理功能中发挥重要作用，包括盐稳态、液体运输和细胞迁移。越来越多的证据表明，ENaC/DEG通道在癌细胞生物学中起着关键作用，如增殖、迁移、侵袭和凋亡，在肿瘤的发生和发展中发挥作用。在本综述中，我们将讨论最近的研究，这些研究表明ENaC和ASIC通道在上皮细胞中的作用及其与肿瘤发生的关系。
相似文献
1
ENaC/DEG in Tumor Development and Progression.上皮钠通道/退化素在肿瘤发生发展中的作用
J Cancer. 2016 Sep 13;7(13):1888-1891. doi: 10.7150/jca.15693. eCollection 2016.
2
The bile acid-sensitive ion channel (BASIC), the ignored cousin of ASICs and ENaC.胆汁酸敏感离子通道（BASIC），酸敏感离子通道（ASICs）和上皮钠通道（ENaC）被忽视的同类物。
Channels (Austin). 2014;8(1):29-34. doi: 10.4161/chan.27493. Epub 2013 Dec 23.
3
The function and regulation of acid-sensing ion channels (ASICs) and the epithelial Na(+) channel (ENaC): IUPHAR Review 19.酸敏感离子通道（ASICs）和上皮钠通道（ENaC）的功能与调节：IUPHAR综述19
Br J Pharmacol. 2016 Sep;173(18):2671-701. doi: 10.1111/bph.13533. Epub 2016 Aug 10.
4
International Union of Basic and Clinical Pharmacology. XCI. structure, function, and pharmacology of acid-sensing ion channels and the epithelial Na+ channel.国际基础和临床药理学联合会. XCI. 酸敏离子通道和上皮钠通道的结构、功能和药理学。
Pharmacol Rev. 2015;67(1):1-35. doi: 10.1124/pr.114.009225.
5
Physiological insight into the conserved properties of Caenorhabditis elegans acid-sensing degenerin/epithelial sodium channels.对秀丽隐杆线虫酸感应性失活退化素/上皮钠通道保守特性的生理学认识。
J Physiol. 2023 May;601(9):1625-1653. doi: 10.1113/JP283238. Epub 2022 Oct 23.
6
A Na leak channel cloned from extends extracellular pH and Ca sensing for the DEG/ENaC family close to the base of Metazoa.从 克隆的一个 Na 泄漏通道使 DEG/ENaC 家族的细胞外 pH 和 Ca 感觉延伸到原生动物的基部附近。
J Biol Chem. 2019 Nov 1;294(44):16320-16336. doi: 10.1074/jbc.RA119.010542. Epub 2019 Sep 15.
7
DEG/ENaC/ASIC channels vary in their sensitivity to anti-hypertensive and non-steroidal anti-inflammatory drugs.DEG/ENaC/ASIC 通道对降压药和非甾体抗炎药的敏感性存在差异。
J Gen Physiol. 2021 Apr 5;153(4). doi: 10.1085/jgp.202012655.
8
Potential Roles of Amiloride-Sensitive Sodium Channels in Cancer Development.氨氯地平敏感钠通道在癌症发展中的潜在作用。
Biomed Res Int. 2016;2016:2190216. doi: 10.1155/2016/2190216. Epub 2016 Jun 15.
9
The nonproton ligand of acid-sensing ion channel 3 activates mollusk-specific FaNaC channels via a mechanism independent of the native FMRFamide peptide.酸敏离子通道 3 的非质子配体通过一种与天然 FMRFamide 肽无关的机制激活软体动物特异性 FaNaC 通道。
J Biol Chem. 2017 Dec 29;292(52):21662-21675. doi: 10.1074/jbc.M117.814707. Epub 2017 Nov 9.
10
ENaCs and ASICs as therapeutic targets.ENaCs 和 ASICs 作为治疗靶点。
Am J Physiol Cell Physiol. 2012 Apr 1;302(7):C943-65. doi: 10.1152/ajpcell.00019.2012. Epub 2012 Jan 25.
引用本文的文献
1
Energy deficiency selects crowded live epithelial cells for extrusion.能量缺乏会选择拥挤的活上皮细胞进行挤压。
Nature. 2025 Sep 10. doi: 10.1038/s41586-025-09514-w.
2
Stable overexpression of the epithelial sodium channel alpha subunit reduces migration and proliferation in breast cancer cells.上皮钠通道α亚基的稳定过表达可降低乳腺癌细胞的迁移和增殖。
Breast Cancer Res Treat. 2025 Jun;211(3):595-604. doi: 10.1007/s10549-025-07667-w. Epub 2025 Apr 12.
3
Acid-sensing ion channel 3 is a new potential therapeutic target for the control of glioblastoma cancer stem cells growth.酸敏离子通道 3 是控制神经胶质瘤肿瘤干细胞生长的新的潜在治疗靶点。
Sci Rep. 2024 Sep 3;14(1):20421. doi: 10.1038/s41598-024-71623-9.
4
Amiloride reduces fructosamine-3-kinase expression to restore sunitinib sensitivity in renal cell carcinoma.氨氯吡咪可降低果糖胺-3-激酶的表达，以恢复肾细胞癌对舒尼替尼的敏感性。
iScience. 2024 May 16;27(6):109997. doi: 10.1016/j.isci.2024.109997. eCollection 2024 Jun 21.
5
Upregulation of α-ENaC induces pancreatic β-cell dysfunction, ER stress, and SIRT2 degradation.α-ENaC的上调会诱导胰腺β细胞功能障碍、内质网应激和SIRT2降解。
J Biomed Res. 2024 May 21;38(3):241-255. doi: 10.7555/JBR.37.20230128.
6
SVM-DO: identification of tumor-discriminating mRNA signatures via support vector machines supported by Disease Ontology.SVM-DO：通过由疾病本体论支持的支持向量机识别肿瘤鉴别mRNA特征
Turk J Biol. 2023 Dec 14;47(6):349-365. doi: 10.55730/1300-0152.2670. eCollection 2023.
7
Proton-sensing ion channels, GPCRs and calcium signaling regulated by them: implications for cancer.质子感应离子通道、G蛋白偶联受体及其调控的钙信号传导：对癌症的影响
Front Cell Dev Biol. 2024 Mar 5;12:1326231. doi: 10.3389/fcell.2024.1326231. eCollection 2024.
8
The role of metal ions in the occurrence, progression, drug resistance, and biological characteristics of gastric cancer.金属离子在胃癌发生、发展、耐药性及生物学特性中的作用。
Front Pharmacol. 2024 Feb 2;15:1333543. doi: 10.3389/fphar.2024.1333543. eCollection 2024.
9
Molecular Basis for Mambalgin-2 Interaction with Heterotrimeric α-ENaC/ASIC1a/γ-ENaC Channels in Cancer Cells.Mambalgin-2 与癌细胞中异三聚体 α-ENaC/ASIC1a/γ-ENaC 通道相互作用的分子基础。
Toxins (Basel). 2023 Oct 13;15(10):612. doi: 10.3390/toxins15100612.
10
Ion Channels as Potential Tools for the Diagnosis, Prognosis, and Treatment of HPV-Associated Cancers.离子通道作为 HPV 相关癌症的诊断、预后和治疗的潜在工具。
Cells. 2023 May 12;12(10):1376. doi: 10.3390/cells12101376.
本文引用的文献
1
Reducing αENaC expression in the kidney connecting tubule induces pseudohypoaldosteronism type 1 symptoms during K+ loading.在肾脏连接小管中降低αENaC表达会在钾负荷增加时诱发1型假性醛固酮减少症症状。
Am J Physiol Renal Physiol. 2016 Feb 15;310(4):F300-10. doi: 10.1152/ajprenal.00258.2015. Epub 2015 Nov 18.
2
Genes Regulating Epithelial Polarity Are Critical Suppressors of Esophageal Oncogenesis.调控上皮细胞极性的基因是抑制食管发生癌变的关键。
J Cancer. 2015 Jun 11;6(8):694-700. doi: 10.7150/jca.11709. eCollection 2015.
3
Regulation of the epithelial Na+ channel by the mTORC2/SGK1 pathway.mTORC2/SGK1 信号通路对上皮钠离子通道的调控
Nephrol Dial Transplant. 2016 Feb;31(2):200-5. doi: 10.1093/ndt/gfv270. Epub 2015 Jul 9.
4
Voltage-gated ion channels in cancer cell proliferation.癌细胞增殖中的电压门控离子通道
Cancers (Basel). 2015 May 22;7(2):849-75. doi: 10.3390/cancers7020813.
5
Cancer as a channelopathy: ion channels and pumps in tumor development and progression.癌症作为一种离子通道病：肿瘤发生与进展中的离子通道和泵
Front Cell Neurosci. 2015 Mar 17;9:86. doi: 10.3389/fncel.2015.00086. eCollection 2015.
6
Involvement of acid-sensing ion channel 1α in hepatic carcinoma cell migration and invasion.酸敏感离子通道1α在肝癌细胞迁移和侵袭中的作用
Tumour Biol. 2015 Jun;36(6):4309-17. doi: 10.1007/s13277-015-3070-6. Epub 2015 Jan 23.
7
Epoxyeicosatrienoic acids attenuating hypotonic-induced apoptosis of IMCD cells via γ-ENaC inhibition.
PLoS One. 2014 Apr 8;9(4):e94400. doi: 10.1371/journal.pone.0094400. eCollection 2014.
8
Ion channels in cancer: future perspectives and clinical potential.癌症中的离子通道：未来展望与临床潜力
Philos Trans R Soc Lond B Biol Sci. 2014 Feb 3;369(1638):20130108. doi: 10.1098/rstb.2013.0108. Print 2014 Mar 19.
9
Cystic fibrosis transmembrane regulator (CFTR) in human trophoblast BeWo cells and its relation to cell migration.人滋养层细胞中的囊性纤维化跨膜转导调节因子（CFTR）及其与细胞迁移的关系。
Placenta. 2014 Feb;35(2):92-8. doi: 10.1016/j.placenta.2013.12.004. Epub 2013 Dec 21.
10
The migratory capacity of human trophoblastic BeWo cells: effects of aldosterone and the epithelial sodium channel.人滋养层细胞 BeWo 的迁移能力：醛固酮和上皮钠通道的影响。
J Membr Biol. 2013 Mar;246(3):243-55. doi: 10.1007/s00232-013-9526-y. Epub 2013 Jan 26.
Zotero 插件