Liu Cui, Zhu Li-Li, Xu Si-Guang, Ji Hong-Long, Li Xiu-Min
School of Nursing, Xinxiang Medical University, Xinxiang 453003, Henan Province, P. R. China.
Institute of Lung and Molecular Therapy, Xinxiang Medical University, Xinxiang 453003, Henan Province, P. R. China.
J Cancer. 2016 Sep 13;7(13):1888-1891. doi: 10.7150/jca.15693. eCollection 2016.
The epithelial Na channel/degenerin (ENaC/DEG) superfamily, including the acid-sensing ion channels (ASICs), is characterized by a high degree of similarity in structure but highly diverse in physiological functions. These ion channels have been shown to be important in several physiological functions of normal epithelial cells, including salt homeostasis, fluid transportation and cell mobility. There is increasing evidence suggesting that ENaC/DEG channels are critically engaged in cancer cell biology, such as proliferation, migration, invasion and apoptosis, playing a role in tumor development and progression. In this review, we will discuss recent studies showing the role of ENaC and ASIC channels in epithelial cells and its relationship to the oncogenesis.
上皮钠通道/退化素（ENaC/DEG）超家族，包括酸敏感离子通道（ASICs），其特点是结构高度相似，但生理功能却高度多样。这些离子通道已被证明在正常上皮细胞的多种生理功能中发挥重要作用，包括盐稳态、液体运输和细胞迁移。越来越多的证据表明，ENaC/DEG通道在癌细胞生物学中起着关键作用，如增殖、迁移、侵袭和凋亡，在肿瘤的发生和发展中发挥作用。在本综述中，我们将讨论最近的研究，这些研究表明ENaC和ASIC通道在上皮细胞中的作用及其与肿瘤发生的关系。
