Shafaghi Afshin, Pourkazemi Aydin, Khosravani Mohsen, Fakhrie Asl Saba, Amir Maafi Alireza, Atrkar Roshan Zahra, Abaspour Rahimabad Jafar
Member of Gastrointestinal and Liver Diseases Research Center(GLDRC) and Gastroenterology Department, Guilan University of Medical Sciences, Rasht, Iran gjhsdfgjfdh.
Infectious Disease Department, Guilan University of Medical Sciences, Rasht, Iran.
Middle East J Dig Dis. 2016 Jul;8(3):179-188. doi: 10.15171/mejdd.2016.30.
BACKGROUND Standard anti-H () treatment fails in the eradication of the organism in almost 10-35% of the patients and has different side effects. Recent studies have proposed that probiotic supplementations with or without prebiotic may improve the eradication rate and diminish the side effects, although it is still a controversial issue. We aimed to investigate the effect of probiotic with prebiotic supplementation on the eradication rate and side effects of anti quadruple therapy. METHODS 76 patients with a positive biopsy specimen for were enrolled. They were randomized to receive quadruple therapy of bismuth, clarithromycin, amoxicillin, and omeprazole for 14 days and also the synbiotic or the placebo. We asked them to answer study questionnaires at the beginning and during the treatment. Finally, urea breath test was done 8 weeks after the treatment. RESULTS The eradication rate was significantly better in the synbiotic group by intention-to-treat analysis (p<0.05). Treatment side effects such as diarrhea, nausea, vomiting, epigastric pain, flatulence, constipation, and taste abnormality were similar in both groups but anorexia was significantly better in the synbiotic group (p <0.05). CONCLUSION The eradication rate was significantly better in the synbiotic group by intention-to-treat analysis (p<0.05). Treatment side effects such as diarrhea, nausea, vomiting, epigastric pain, flatulence, but could improve the eradication by augmenting the treatment tolerance and compliance.
标准的抗幽门螺杆菌（H）治疗在近10%-35%的患者中无法根除该病菌，且有不同的副作用。近期研究表明，补充益生菌（无论是否添加益生元）可能会提高根除率并减少副作用，尽管这仍是一个有争议的问题。我们旨在研究补充益生菌和益生元对根除率及抗幽门螺杆菌四联疗法副作用的影响。方法：招募了76例活检标本幽门螺杆菌呈阳性的患者。他们被随机分为两组，一组接受铋剂、克拉霉素、阿莫西林和奥美拉唑的四联疗法治疗14天，并同时服用合生元或安慰剂。我们要求他们在治疗开始时和治疗期间回答研究问卷。最后，在治疗8周后进行尿素呼气试验。结果：意向性分析显示，合生元组的根除率显著更高（p<0.05）。两组的腹泻、恶心、呕吐、上腹部疼痛、肠胃胀气、便秘和味觉异常等治疗副作用相似，但合生元组的食欲不振情况明显更好（p<0.05）。结论：意向性分析显示，合生元组的根除率显著更高（p<0.05）。腹泻、恶心、呕吐、上腹部疼痛、肠胃胀气等治疗副作用虽相似，但合生元可通过提高治疗耐受性和依从性来提高根除率。
