Xenopoulou Evangelia, Kontele Ioanna, Sergentanis Theodoros N, Grammatikopoulou Maria G, Tzoutzou Milia, Kotrokois Konstantinos, Tsitsika Artemis Κ, Vassilakou Tonia
Laboratory of Epidemiology, Health Determinants and Well-Being, Department of Public Health Policy, University of West Attica, 115 21 Athens, Greece.
Department of Rheumatology and Clinical Immunology, Faculty of Medicine, School of Health Sciences, University of Thessaly, Biopolis, 411 10 Larissa, Greece.
Children (Basel). 2024 Mar 9;11(3):329. doi: 10.3390/children11030329.
Recently, there has been an increasing interest in the association of gut microbiota with health conditions and the potentially beneficial role of several types of biotics in several population groups, including children and adolescents. Children and adolescents comprise a unique population group due their rapid growth rates, high nutritional requirements, the immaturity of their immune system in early life, and their susceptibility to infectious diseases. The aim of the present study is to investigate the role and limitations of the administration of biotics in specific conditions affecting children and adolescents. A narrative review of related articles published on PubMed up to October 2023 was conducted. The administration of biotics has been evaluated in several health conditions among children and adolescents, such as the treatment and prevention of infectious diarrhea, the prevention of diarrhea after the use of antibiotics, the prevention of necrotizing enterocolitis, the treatment of functional gastrointestinal diseases, such as infant colic, functional abdominal pain, and irritable bowel syndrome, the eradication of , the treatment of ulcerative colitis and pouchitis, and the prevention of atopic dermatitis, and the findings indicate improved symptoms and various beneficial health outcomes. However, some limitations have been identified regarding probiotics' use. In conclusion, biotics may have a beneficial impact in several health conditions among children and adolescents. There is a need for additional randomized, controlled clinical studies on the effects of the administration of biotics in children and particularly in adolescents and young adults.
最近，肠道微生物群与健康状况之间的关联以及几种类型的生物制剂在包括儿童和青少年在内的几类人群中可能具有的有益作用越来越受到关注。儿童和青少年因其快速的生长速度、高营养需求、生命早期免疫系统不成熟以及对传染病的易感性而构成一个独特的人群。本研究的目的是探讨生物制剂在影响儿童和青少年的特定状况中的作用和局限性。对截至2023年10月在PubMed上发表的相关文章进行了叙述性综述。已在儿童和青少年的多种健康状况中评估了生物制剂的施用情况，如感染性腹泻的治疗和预防、使用抗生素后腹泻的预防、坏死性小肠结肠炎的预防、功能性胃肠疾病（如婴儿腹绞痛、功能性腹痛和肠易激综合征）的治疗、根除幽门螺杆菌、溃疡性结肠炎和储袋炎的治疗以及特应性皮炎的预防，研究结果表明症状有所改善且有各种有益的健康结局。然而，已确定益生菌使用存在一些局限性。总之，生物制剂可能对儿童和青少年的多种健康状况产生有益影响。需要针对生物制剂施用对儿童尤其是青少年和青年的影响开展更多随机对照临床研究。
