Jiang Feng, Hu Wei, Zhang Bicheng, Xu Jing, Shui Yongjie, Zhou Xiaofeng, Ren Xiaoqiu, Chen Xiaozhong, Shen Li, Wei Qichun
Department of Radiation Oncology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, P.R. China; Department of Radiation Oncology, Zhejiang Cancer Hospital, Hangzhou, Zhejiang 310022, P.R. China.
National Ministry of Education Key Laboratory of Cancer Prevention and Intervention, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, P.R. China.
Biomed Rep. 2016 Oct;5(4):437-442. doi: 10.3892/br.2016.757. Epub 2016 Sep 12.
In the era of intensity-modulated radiotherapy, distant metastasis is currently the main cause of treatment failure for nasopharyngeal carcinoma (NPC). Additional therapeutic strategies are required to control the metastasis and improve survival. One strategy is targeted therapy, for example against c-Kit. In the current study, the frequency of c-Kit expression was determined immunohistochemically in 106 NPC patients. c-Kit expression changes during the course of radiation therapy were detected in 41 cases via weekly biopsy. Twelve cases (11.3%) had c-Kit expression scores of 3 and 16 (15.1%) had scores of 2. Thus, c-Kit overexpression (2 or 3) was observed in 28 (26.4%) patients. There were 35 (33.0%) and 43 (40.6%) patients with c-Kit expression scores of 1 and 0, respectively. Furthermore, a trend of decreased c-Kit expression was observed after commencing radiotherapy according to the 41 NPC patients who were biopsied weekly. Therefore, c-Kit overexpression was identified to be common in NPC, and evaluating c-Kit as a therapeutic target for metastatic NPC via c-Kit overexpression subsequent to first line treatment may be of interest. To the best of our knowledge, the present study is the first to demonstrate a trend of decreased c-Kit expression during the course of radiotherapy.
在调强放射治疗时代，远处转移是目前鼻咽癌（NPC）治疗失败的主要原因。需要额外的治疗策略来控制转移并提高生存率。一种策略是靶向治疗，例如针对c-Kit。在本研究中，通过免疫组织化学方法测定了106例NPC患者中c-Kit的表达频率。通过每周活检在41例患者中检测了放射治疗过程中c-Kit的表达变化。12例（11.3%）患者的c-Kit表达评分为3分，16例（15.1%）患者的评分为2分。因此，28例（26.4%）患者出现c-Kit过表达（2或3分）。c-Kit表达评分为1分和0分的患者分别有35例（33.0%）和43例（40.6%）。此外，根据每周接受活检的41例NPC患者，在开始放疗后观察到c-Kit表达有下降趋势。因此，c-Kit过表达在NPC中很常见，通过一线治疗后c-Kit过表达将c-Kit评估为转移性NPC的治疗靶点可能具有重要意义。据我们所知，本研究是首次证明放疗过程中c-Kit表达有下降趋势的研究。
