Busch David R, Rusin Craig G, Miller-Hance Wanda, Kibler Kathy, Baker Wesley B, Heinle Jeffrey S, Fraser Charles D, Yodh Arjun G, Licht Daniel J, Brady Kenneth M
Division of Neurology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA; Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, PA 19104, USA.
Departments of Pediatrics and Cardiology, Baylor College of Medicine, Houston, TX, 77030 USA.
Biomed Opt Express. 2016 Aug 15;7(9):3461-3470. doi: 10.1364/BOE.7.003461. eCollection 2016 Sep 1.
While survival of children with complex congenital heart defects has improved in recent years, roughly half suffer neurological deficits suspected to be related to cerebral ischemia. Here we report the first demonstration of optical diffuse correlation spectroscopy (DCS) for continuous and non-invasive monitoring of cerebral microvascular blood flow during complex human neonatal or cardiac surgery. Comparison between DCS and Doppler ultrasound flow measurements during deep hypothermia, circulatory arrest, and rewarming were in good agreement. Looking forward, DCS instrumentation, alone and with NIRS, could provide access to flow and metabolic biomarkers needed by clinicians to adjust neuroprotective therapy during surgery.
近年来，患有复杂先天性心脏缺陷的儿童的存活率有所提高，但仍有大约一半的儿童存在疑似与脑缺血相关的神经功能缺损。在此，我们报告了首次利用光学扩散相关光谱法（DCS）对复杂的新生儿或心脏手术期间的脑微血管血流进行连续、无创监测。在深度低温、循环停止和复温期间，DCS与多普勒超声血流测量结果之间的比较结果高度一致。展望未来，单独使用DCS仪器以及将其与近红外光谱技术（NIRS）结合使用，可为临床医生在手术期间调整神经保护治疗所需的血流和代谢生物标志物提供检测手段。
