Matsui Y, Kashii S, Sasa M, Takaori S, Honda Y
Department of Pharmacology, Faculty of Medicine, Kyoto University, Japan.
Jpn J Pharmacol. 1989 Jun;50(2):119-24. doi: 10.1254/jjp.50.119.
Effects of ethanol on optokinetic, vestibular and caloric nystagmus were investigated in pigmented rabbits to determine whether or not it affects a specific site involved in the induction of various nystagmus. Optokinetic nystagmus was produced by rotation of the drum with vertical stripes at an angular velocity of 0.85 degrees/sec. Vestibular nystagmus was induced by horizontal rotation at an angular velocity of 30 degrees/sec and caloric nystagmus by infusion of cold water into the external meatus. Cumulative injection of ethanol into the auricular vein to doses of 0.1, 0.2, 0.4 and 0.8 g/kg inhibited both vestibular and caloric nystagmus dose-dependently, but did not affect the optokinetic nystagmus. These results suggest that relatively low doses of ethanol mainly act on the peripheral vestibular organ and impair the vestibular function without affecting the optokinetic system.
在有色家兔中研究了乙醇对视动性、前庭性和冷热性眼震的影响，以确定它是否影响参与各种眼震诱发的特定部位。视动性眼震通过以0.85度/秒的角速度旋转带有垂直条纹的鼓来产生。前庭性眼震通过以30度/秒的角速度水平旋转诱发，冷热性眼震通过向外耳道注入冷水诱发。向耳静脉累积注射乙醇至剂量为0.1、0.2、0.4和0.8克/千克，剂量依赖性地抑制前庭性和冷热性眼震，但不影响视动性眼震。这些结果表明，相对低剂量的乙醇主要作用于外周前庭器官，损害前庭功能而不影响视动系统。
