Panahi Y, Mohammadhosseini M, Abadi A J N, Akbarzadeh A, Mellatyar H
Chemical Injuries Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.
Department of Chemistry, Shahrood Branch, Islamic Azad University, Shahrood, Iran.
Drug Res (Stuttg). 2016 Nov;66(11):580-586. doi: 10.1055/s-0042-112811. Epub 2016 Oct 4.
Approximately 35 million people worldwide suffer from Alzheimer's disease (AD). The cellular uptake and specific transport of drugs and imaging agents to brain are common issues in the diagnosis and therapy of AD. New advances in nanotechnology have supplied favorable solutions to this issue. Various nanocarriers such as polymeric nanoparticles, liposomes, micelles, dendrimers and nanogels have been studied for the delivery of drugs and imaging agents to brain. This review presents a succinct discussion of the applications of nanotechnology for Alzheimer's disease diagnosis and therapy.
全球约有3500万人患有阿尔茨海默病（AD）。药物和成像剂向大脑的细胞摄取及特异性转运是AD诊断和治疗中的常见问题。纳米技术的新进展为这一问题提供了有利的解决方案。各种纳米载体，如聚合物纳米颗粒、脂质体、胶束、树枝状大分子和纳米凝胶，已被研究用于将药物和成像剂递送至大脑。本文综述简要讨论了纳米技术在阿尔茨海默病诊断和治疗中的应用。
