Venkatraman Subbu S, Ma Lwin Lwin, Natarajan Jayaganesh V, Chattopadhyay Sujay
School of Material Science and Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore.
Front Biosci (Schol Ed). 2010 Jun 1;2(3):801-14. doi: 10.2741/s103.
This review focuses on polymer- and liposome-based nanoparticles used in targeted delivery of bioactive molecules, from drugs to siRNA to pDNA. The perspective centers around commercial and clinical successes, and a rationalization of these successes. Microparticulate systems are not covered, and only those applications that truly utilize the advantages of nano size are covered. "Stealth" systems dominate in this review, as most of the clinical successes are for passive targeting rather than for active targeting of tissue. The relevance of nano size to gene delivery is also discussed with relevant examples.
本综述聚焦于用于生物活性分子靶向递送的基于聚合物和脂质体的纳米颗粒，这些生物活性分子包括从药物到小干扰RNA再到质粒DNA。视角围绕商业和临床成功案例以及对这些成功案例的合理化分析。未涵盖微粒系统，仅涵盖那些真正利用纳米尺寸优势的应用。“隐形”系统在本综述中占主导地位，因为大多数临床成功案例是基于被动靶向而非组织的主动靶向。还通过相关实例讨论了纳米尺寸与基因递送的相关性。
