Lücke A, Lehmenkühler A, Speckmann E J
Institute of Physiology, University of Münster, F.R.G.
J Neurosci Methods. 1989 Aug;29(2):139-42. doi: 10.1016/0165-0270(89)90025-3.
Interference of the epileptogenic drug pentylenetetrazol (PTZ) on the Ca2+-selective microelectrode based on the neutral carrier ETH 1001 is described. It is suggested that tetraphenylborate, a component of the Ca2+-selective membrane, is responsible for this interference. Though the sensitivity of the Ca2+-selective microelectrode to PTZ is low, the error in measurements of the free Ca2+ concentration in biological preparations treated with PTZ has to be considered, since pathological changes in the extracellular Ca2+ concentration also produce relatively small changes in the relative electrode potential.
