基于磁铁矿-金纳米颗粒的纳米杂化材料用于前列腺癌诊断：合成与体外测试

Nanohybride Materials Based on Magnetite-Gold Nanoparticles for Diagnostics of Prostate Cancer: Synthesis and In Vitro Testing.

作者信息

Machulkin A E, Garanina A S, Zhironkina O A, Beloglazkina E K, Zyk N V, Savchenko A G, Kotelyanskii V E, Mazhuga A G

机构信息

Laboratory of Tissue-Specific Ligands, Faculty of Chemistry, M. V. Lomonosov Moscow State University, Moscow, Russia.

Laboratory of Biomedical Nanomaterials, National University of Science and Technology, Moscow Institute of Steel and Alloys (NUST MISiS), Moscow, Russia.

出版信息

Bull Exp Biol Med. 2016 Sep;161(5):706-710. doi: 10.1007/s10517-016-3490-3. Epub 2016 Oct 4.

DOI:10.1007/s10517-016-3490-3

PMID:27704352

Abstract

We synthesized a fluorescence conjugate and modified magnetite-gold nanoparticles carrying prostate specific membrane antigen (PSMA) as the ligand. Analysis of their binding to human prostate cancer cell lines PC-3 (PSMA) and LNCaP (PSMA) showed selective interaction of the synthesized conjugate and modified nanoparticles with LNCaP cells. These findings suggest that these nanoparticles can be used in tissue-specific magnetic-resonance imaging.

摘要

我们合成了一种荧光共轭物，并对负载前列腺特异性膜抗原（PSMA）作为配体的磁铁矿-金纳米颗粒进行了修饰。对其与人类前列腺癌细胞系PC-3（PSMA）和LNCaP（PSMA）结合的分析表明，合成的共轭物和修饰后的纳米颗粒与LNCaP细胞存在选择性相互作用。这些发现表明，这些纳米颗粒可用于组织特异性磁共振成像。