Giarelli L, Grandi G, Delendi M, Falconieri G
University of Trieste, Department of Anatomic Pathology, Ospedale Maggiore, Trieste, Italy.
Metab Pediatr Syst Ophthalmol (1985). 1989;12(1-3):61-3.
The pathology of the optic nerve in the advanced elderly has been investigated at autopsy in a sample of 50 subjects (43 males, 7 females), aged 95-103 years. Septal fibrous thickness and slendering of nerve fibers were the most frequently encountered lesions as well as degenerative processes involving the cribriform lamina. Other significant features included gliosis, demyelination, and corpora amylacea. Complete arteriosclerotic disease was rarely observed. The results of the present study suggest that optic nerve pathology in aged people is almost the consequence of an inadequate blood supply; nevertheless, the degree of these lesions does not seem to parallel that usually observed in other sites particularly injured by ischemic disease.
对50名年龄在95至103岁之间的受试者（43名男性，7名女性）进行尸检，研究了高龄老年人视神经的病理学情况。隔膜纤维增厚和神经纤维变细是最常见的病变，以及涉及筛板的退行性过程。其他显著特征包括胶质增生、脱髓鞘和淀粉样体。几乎未观察到完全性动脉硬化疾病。本研究结果表明，老年人的视神经病理学几乎是血液供应不足的结果；然而，这些病变的程度似乎与通常在其他受缺血性疾病特别损伤的部位观察到的程度不平行。
