Giarelli L, Grandi G, Delendi M, Falconieri G
Institute of Pathological Anatomy and Histology, University of Trieste, Italy.
Metab Pediatr Syst Ophthalmol (1985). 1986;9(2-4):71-3.
The pathology of optic nerve in 80 diabetic subjects has been investigated in a morphologic study performed on autoptic material. Gliosis and demyelination resulted as the most frequently observed lesions (respectively 19 and 18 cases) and were associated to long history of diabetes. Additional findings were focal infarctions, atrophy, and broad spectrum of vascular lesions, mostly affecting the microcirculation, including thickening, hyalinosis, microaneurysms, as well as thromboses. An age-sex-matched control group, made of non diabetic subjects, did not share significantly lesions with the diabetics. Therefore, the authors suggest that diabetes mellitus plays an important role in the development of pathological changes in the optic nerves, thus claiming the marked vascular damage of early age onset diabetes as a possible pathogenetic factor.
在一项对尸检材料进行的形态学研究中，对80名糖尿病患者的视神经病理学进行了调查。胶质增生和脱髓鞘是最常观察到的病变（分别为19例和18例），且与糖尿病病史较长有关。其他发现包括局灶性梗死、萎缩以及广泛的血管病变，主要影响微循环，包括增厚、玻璃样变性、微动脉瘤以及血栓形成。由非糖尿病受试者组成的年龄性别匹配对照组与糖尿病患者没有明显共同的病变。因此，作者认为糖尿病在视神经病理变化的发展中起重要作用，从而声称早发型糖尿病明显的血管损伤是一个可能的致病因素。
