Loeffler K U, Edward D P, Tso M O
Georgiana Dvorak Theobald Ophthalmic Pathology Laboratory, Department of Ophthalmology and Visual Sciences, University of Illinois, Chicago College of Medicine 60612.
Invest Ophthalmol Vis Sci. 1993 Jul;34(8):2600-3.
To characterize the constituents of corpora amylacea in the human retina and optic nerve.
Immunohistochemistry was performed on sections of retina, optic nerve, and brain tissue using antibodies against tau 1, tau-2, and amyloid precursor protein.
Consistent anti-tau-2 immunoreactivity was noted in the corpora amylacea in the retina, optic nerve, and brain tissue, albeit with variations in pattern and intensity of staining. No immunoreactivity was observed with antibodies anti-tau 1 and anti-amyloid precursor protein.
Our findings suggest the accumulation of possibly abnormal tau-2 within the corpora amylacea, which may be either astrocytic or axonal in origin.
鉴定人类视网膜和视神经中淀粉样体的成分。
使用抗tau 1、tau-2和淀粉样前体蛋白的抗体对视网膜、视神经和脑组织切片进行免疫组织化学检测。
在视网膜、视神经和脑组织的淀粉样体中观察到一致的抗tau-2免疫反应性，尽管染色模式和强度存在差异。抗tau 1和抗淀粉样前体蛋白抗体未观察到免疫反应性。
我们的研究结果表明，淀粉样体内可能存在异常tau-2的积累，其起源可能是星形细胞或轴突。
