Lepore L, Longo F, Mascarin M, Toscano C
Minerva Pediatr. 1989 Apr;41(4):205-8.
Salivary IgA were examined in a group of children with recurring respiratory infections (RRI) in order to complete research into the immunological profile of such children. IgA assays were performed in 21 children suffering from RRI both in the remission period (Summer) and during infections (Winter). No children revealed any real disorder in basic salivary IgA. Salivary IgA levels were however about ten times higher in the Winter (the infection period). In a control group of 15 healthy children in the same age range, IgA levels were also high in the winter but still lower than those found in the RRI group. It is therefore concluded that children with RRI do not, as has often been suggested, present any basic disorder in salivary IgA, but that the response of secretory IgA is far more sensitive to infection than the system as a whole.
为了完善对患有反复呼吸道感染(RRI)儿童免疫特征的研究,对一组患有反复呼吸道感染的儿童进行了唾液免疫球蛋白A(IgA)检测。对21名患有反复呼吸道感染的儿童在缓解期(夏季)和感染期(冬季)进行了IgA检测。没有儿童显示出基础唾液IgA有任何真正的紊乱。然而,冬季(感染期)唾液IgA水平约高出十倍。在一个由15名同龄健康儿童组成的对照组中,冬季IgA水平也较高,但仍低于反复呼吸道感染组。因此得出结论,患有反复呼吸道感染的儿童并不像人们常认为的那样,存在基础唾液IgA紊乱,而是分泌型IgA对感染的反应比整个免疫系统更为敏感。