Okuyama Teruhiro, Kitamura Takashi, Roy Dheeraj S, Itohara Shigeyoshi, Tonegawa Susumu
RIKEN-MIT Center for Neural Circuit Genetics at the Picower Institute for Learning and Memory, Department of Biology and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology (MIT), Cambridge, MA 02139, USA.
Brain Science Institute, RIKEN, Saitama, 351-0198, Japan.
Science. 2016 Sep 30;353(6307):1536-1541. doi: 10.1126/science.aaf7003.
The medial temporal lobe, including the hippocampus, has been implicated in social memory. However, it remains unknown which parts of these brain regions and their circuits hold social memory. Here, we show that ventral hippocampal CA1 (vCA1) neurons of a mouse and their projections to nucleus accumbens (NAc) shell play a necessary and sufficient role in social memory. Both the proportion of activated vCA1 cells and the strength and stability of the responding cells are greater in response to a familiar mouse than to a previously unencountered mouse. Optogenetic reactivation of vCA1 neurons that respond to the familiar mouse enabled memory retrieval and the association of these neurons with unconditioned stimuli. Thus, vCA1 neurons and their NAc shell projections are a component of the storage site of social memory.
包括海马体在内的内侧颞叶与社交记忆有关。然而，这些脑区及其神经回路的哪些部分承载着社交记忆仍不清楚。在这里，我们表明，小鼠腹侧海马CA1（vCA1）神经元及其向伏隔核（NAc）壳的投射在社交记忆中起着必要且充分的作用。与先前未接触过的小鼠相比，vCA1细胞的激活比例以及反应细胞的强度和稳定性在对熟悉小鼠的反应中更大。对熟悉小鼠有反应的vCA1神经元的光遗传学重新激活能够实现记忆检索，并使这些神经元与非条件刺激相关联。因此，vCA1神经元及其NAc壳投射是社交记忆存储位点的一个组成部分。
