空间基因组组织与认知。
Spatial genome organization and cognition.
作者信息
Rajarajan Prashanth, Gil Sergio Espeso, Brennand Kristen J, Akbarian Schahram
机构信息
Department of Psychiatry, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, 10029 New York, USA.
Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Dr. Aiguader 88, Barcelona 08003, Spain.
出版信息
Nat Rev Neurosci. 2016 Nov;17(11):681-691. doi: 10.1038/nrn.2016.124. Epub 2016 Oct 6.
Abstract
Nonrandom chromosomal conformations, including promoter-enhancer loopings that bypass kilobases or megabases of linear genome, provide a crucial layer of transcriptional regulation and move vast amounts of non-coding sequence into the physical proximity of genes that are important for neurodevelopment, cognition and behaviour. Activity-regulated changes in the neuronal '3D genome' could govern transcriptional mechanisms associated with learning and plasticity, and loop-bound intergenic and intronic non-coding sequences have been implicated in psychiatric and adult-onset neurodegenerative disease. Recent studies have begun to clarify the roles of spatial genome organization in normal and abnormal cognition.
摘要
非随机染色体构象，包括跨越线性基因组数千碱基或数百万碱基的启动子-增强子环化，提供了转录调控的关键层面，并使大量非编码序列移至对神经发育、认知和行为至关重要的基因的物理邻近区域。神经元“三维基因组”中由活动调节的变化可能控制与学习和可塑性相关的转录机制，并且环结合的基因间和内含子非编码序列已被认为与精神疾病和成人起病的神经退行性疾病有关。最近的研究已开始阐明空间基因组组织在正常和异常认知中的作用。
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Mol Psychiatry. 2017 Jun;22(6):836-849. doi: 10.1038/mp.2016.84. Epub 2016 May 31.
2
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Nature. 2016 May 5;533(7601):95-9. doi: 10.1038/nature17939. Epub 2016 Apr 20.
3
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Nat Med. 2016 Apr;22(4):345-61. doi: 10.1038/nm.4071.
4
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