转录激活的层次结构：从增强子到启动子。

The Hierarchy of Transcriptional Activation: From Enhancer to Promoter.

机构信息

The Roslin Institute, Developmental Biology Division, University of Edinburgh, Easter Bush, Midlothian EH25 9RG, UK.

MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK.

出版信息

Trends Genet. 2015 Dec;31(12):696-708. doi: 10.1016/j.tig.2015.10.004.

DOI:10.1016/j.tig.2015.10.004

PMID:26599498

Abstract

Regulatory elements (enhancers) that are remote from promoters play a critical role in the spatial, temporal, and physiological control of gene expression. Studies on specific loci, together with genome-wide approaches, suggest that there may be many common mechanisms involved in enhancer-promoter communication. Here, we discuss the multiprotein complexes that are recruited to enhancers and the hierarchy of events taking place between regulatory elements and promoters.

摘要

调控元件（增强子）远离启动子，在基因表达的时空和生理控制中起着关键作用。对特定基因座的研究以及全基因组方法表明，增强子-启动子通讯可能涉及许多共同的机制。在这里，我们讨论了募集到增强子的多蛋白复合物以及在调控元件和启动子之间发生的事件的层次结构。