Moses K, Ellis M C, Rubin G M
Howard Hughes Medical Institute, Department of Biochemistry, University of California, Berkeley 94720.
Nature. 1989 Aug 17;340(6234):531-6. doi: 10.1038/340531a0.
Null mutations of glass specifically remove photoreceptor cells, leaving other cell types intact. We have isolated the glass gene and have shown that its transcript encodes a putative protein of 604 amino acids with five zinc-fingers. The glass product may be a transcription factor required for the development of a single neuronal cell type.
glass基因的无效突变特异性地消除了光感受器细胞,而其他细胞类型保持完整。我们已经分离出glass基因,并表明其转录本编码一种含有五个锌指的604个氨基酸的推定蛋白质。glass基因产物可能是单一神经元细胞类型发育所需的转录因子。