Ranek L
Arch Toxicol Suppl. 1978(1):137-9. doi: 10.1007/978-3-642-66896-8_15.
Halothane (2-bromo-2-chloro-1:1:1-trifluoroethane) is a volatile, nonflammable anaesthetic agent which has been widely used for the last 20 years. Halothane hepatitis has been a matter of continuing controversy, but now it seems to be generally accepted as a clinical entity. Characteristically the halothane hepatitis occurs after multiple exposures to halothane within short time. The pathogenesis of the liver cell damage is obscure. It is estimated that the incidence of halothane hepatitis is about one per 8000 halothane anaesthesias and the lethality about one per 40000. Prophylaxis consists of avoiding repeated halothane anaesthesias within short time and to avoid re-exposure to halothane if otherwise unexplained liver damage has occurred after halothane.
氟烷（2-溴-2-氯-1:1:1-三氟乙烷）是一种挥发性、不可燃的麻醉剂，在过去20年中被广泛使用。氟烷性肝炎一直存在争议，但现在似乎已被普遍视为一种临床病症。其特点是在短时间内多次接触氟烷后发生氟烷性肝炎。肝细胞损伤的发病机制尚不清楚。据估计，氟烷性肝炎的发病率约为每8000例氟烷麻醉中出现1例，致死率约为每40000例中出现1例。预防措施包括避免在短时间内重复进行氟烷麻醉，以及如果在氟烷麻醉后出现不明原因的肝损伤，应避免再次接触氟烷。
