Khalil-Manesh F, Agness C, Gonick H C
Trace Element Laboratory, Cedars-Sinai Medical Center, Los Angeles, Calif.
Nephron. 1989;52(4):329-33. doi: 10.1159/000185672.
Ultrafiltration experiments, using Amicon membranes with molecular weight exclusions of 1,000, 10,000 and 30,000 daltons, have revealed that Desferal, both in vitro and in vivo, markedly increases aluminum ultrafilterability in plasma from patients with dialysis dementia. Ultrafilterability was greater with the 10,000-dalton membrane (60%) as compared with the 1,000-dalton membrane (40%); the difference could be related to the presence of an 8,000-dalton aluminum-binding protein in the 10,000-dalton filtrate. These observations are pertinent to in vivo dialysis studies which have demonstrated enhanced aluminum clearance with high-permeability polyacrylonitrile dialysis membranes.
使用截留分子量为1000、10000和30000道尔顿的密理博膜进行的超滤实验表明，去铁胺在体外和体内均显著提高了透析性痴呆患者血浆中铝的超滤率。与截留分子量为1000道尔顿的膜（40%）相比，截留分子量为10000道尔顿的膜的超滤率更高（60%）；这种差异可能与截留分子量为10000道尔顿的滤液中存在一种8000道尔顿的铝结合蛋白有关。这些观察结果与体内透析研究相关，体内透析研究已证明使用高通透性聚丙烯腈透析膜可提高铝的清除率。
