Leung F Y, Hodsman A B, Muirhead N, Henderson A R
Clin Chem. 1985 Jan;31(1):20-3.
Using gel filtration chromatography, we evaluated aluminum bound to albumin, transferrin, and other plasma proteins in the serum of patients on maintenance hemodialysis. The proportion of dialyzable aluminum, as determined by selective membrane ultrafiltration and flameless atomic absorption spectrometry, increased by more than fourfold on treatment with the metal chelator, deferoxamine. This ultrafiltration technique may prove useful for monitoring the proportion of aluminum mobilized during such therapy.
我们使用凝胶过滤色谱法评估了维持性血液透析患者血清中与白蛋白、转铁蛋白及其他血浆蛋白结合的铝。通过选择性膜超滤和无火焰原子吸收光谱法测定，在用金属螯合剂去铁胺治疗后，可透析铝的比例增加了四倍多。这种超滤技术可能对监测此类治疗过程中铝的动员比例有用。
