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E3泛素连接酶RNF135调节舌癌SCC25细胞的肿瘤发生活性。

The E3 ubiquitin ligase RNF135 regulates the tumorigenesis activity of tongue cancer SCC25 cells.

作者信息

Jin Jian, Zhao Liya, Li Zubing

机构信息

The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University, Wuhan, 430079, China.

Department of Oral and Maxillofacial Trauma and Plastic Aesthetic Surgery, School & Hospital of Stomatology, Wuhan University, Wuhan, 430079, China.

出版信息

Cancer Med. 2016 Nov;5(11):3140-3146. doi: 10.1002/cam4.832. Epub 2016 Oct 5.

DOI:10.1002/cam4.832
PMID:27709798
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5119969/
Abstract

Several E3 ubiquitin ligases have been confirmed that they are related to the tumorigenesis. This study aims to find the tongue cancer-related E3 ubiquitin ligase. The E3 ubiquitin ligase library was screened. The effect of candidate molecule on tongue cancer was validated through cell viability, cell proliferation, colony formation, invasive assay in vitro, and the xenograft model in vivo. The E3 ubiquitin ligase RNF135 significantly promoted the expression of PTEN and TP53 in SCC25 cells. The overexpression of RNF135 inhibited the viability, proliferation, and invasion of SCC25 cells. Knockdown of RNF135 had the opposite effects. Furthermore, RNF135 regulates the tumorigenesis activity of SCC25 cells in vivo. Our results demonstrated that RNF135 had the potential to affect the development of the tongue cancer in vitro. The further in vivo study is helpful to fully understand the role of it.

摘要

已有几种E3泛素连接酶被证实与肿瘤发生有关。本研究旨在寻找与舌癌相关的E3泛素连接酶。对E3泛素连接酶文库进行了筛选。通过细胞活力、细胞增殖、集落形成、体外侵袭实验以及体内异种移植模型验证了候选分子对舌癌的影响。E3泛素连接酶RNF135显著促进了SCC25细胞中PTEN和TP53的表达。RNF135的过表达抑制了SCC25细胞的活力、增殖和侵袭。敲低RNF135则产生相反的效果。此外，RNF135在体内调节SCC25细胞的肿瘤发生活性。我们的结果表明，RNF135在体外具有影响舌癌发展的潜力。进一步的体内研究有助于全面了解其作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5aaf/5119969/61dd869e478f/CAM4-5-3140-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5aaf/5119969/1d8e9c1ff382/CAM4-5-3140-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5aaf/5119969/8bfa5be42f59/CAM4-5-3140-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5aaf/5119969/4552fbcdd947/CAM4-5-3140-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5aaf/5119969/bd53c5f0f185/CAM4-5-3140-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5aaf/5119969/8c0876e19c48/CAM4-5-3140-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5aaf/5119969/61dd869e478f/CAM4-5-3140-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5aaf/5119969/1d8e9c1ff382/CAM4-5-3140-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5aaf/5119969/8bfa5be42f59/CAM4-5-3140-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5aaf/5119969/4552fbcdd947/CAM4-5-3140-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5aaf/5119969/bd53c5f0f185/CAM4-5-3140-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5aaf/5119969/8c0876e19c48/CAM4-5-3140-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5aaf/5119969/61dd869e478f/CAM4-5-3140-g006.jpg

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