Graben N, Doss M, Klöppel H A
Med Klin. 1978 Aug 4;73(31):1114-6.
A 19-year old male ingested in suicidal attempt 750 mg of thallium. He developed the characteristic symptoms of thallium intoxication. During the acute phase the urinary excretion of porphyrins and porphyrin precursors was largely increased. The percentage distribution of the individual metabolites of heme synthesis revealed a preponderance of kopro- and uroporphyrin. This constellation (kopro- greater than uro- greater than tricarboxylic porphyrin) differs appreciably from that one in lead intoxication. The observation of increased urinary excretion of porphyrins and their precursors in a possibly particular spectrum in thallium intoxication is of special interest for differential-diagnostic reasoning. In each case of a toxic disorder of porphyrin metabolism thallium intoxication ought to be considered a possible cause.
一名19岁男性为自杀企图摄入了750毫克铊。他出现了铊中毒的典型症状。在急性期，卟啉和卟啉前体的尿排泄量大幅增加。血红素合成的各个代谢物的百分比分布显示粪卟啉和尿卟啉占优势。这种组合（粪卟啉＞尿卟啉＞三羧酸卟啉）与铅中毒的情况明显不同。在铊中毒中观察到卟啉及其前体的尿排泄增加且可能具有特定谱型，这对于鉴别诊断推理具有特殊意义。在每一例卟啉代谢中毒性疾病中，都应考虑铊中毒是可能的病因。
