Petroff O A, Spencer D D, Alger J R, Prichard J W
Department of Neurology, Yale University, New Haven, CT 06510.
Neurology. 1989 Sep;39(9):1197-202. doi: 10.1212/wnl.39.9.1197.
We analyzed specimens of histologically normal human cerebrum obtained at surgery for medically refractory epilepsy using proton magnetic resonance spectroscopy. Perchloric acid extracts of anterolateral temporal lobe cortex contained greater concentrations of creatine, N-acetylaspartate, gamma-aminobutyric acid, alanine, and glutamate than the under lying white matter, which contained more acetate. Frontal and temporal lobe specimens composed of both gray and white matter failed to show statistically significant differences in the concentrations of creatine, N-acetylaspartate, alanine, aspartate gamma-aminobutyric acid, glutamate, glycine, taurine, threonine, valine, acetate, choline, beta-hydroxybutyric acid, inositols, lactate pyruvate, or succinate.
我们使用质子磁共振波谱分析了因药物难治性癫痫而在手术中获取的组织学正常的人类大脑标本。前颞叶皮质的高氯酸提取物中肌酸、N - 乙酰天门冬氨酸、γ - 氨基丁酸、丙氨酸和谷氨酸的浓度高于其下方的白质，而白质中乙酸盐含量更高。由灰质和白质组成的额叶和颞叶标本在肌酸、N - 乙酰天门冬氨酸、丙氨酸、天冬氨酸、γ - 氨基丁酸、谷氨酸、甘氨酸、牛磺酸、苏氨酸、缬氨酸、乙酸盐、胆碱、β - 羟基丁酸、肌醇、乳酸/丙酮酸或琥珀酸盐的浓度上未显示出统计学上的显著差异。
