Eun Young-Mi, Kang Sung-Goo, Song Sang-Wook
Sung-goo Kang MD, Department of Family Medicine,, St. Vincent's Hospital, Jungbudaero 93 Jidong,, Suwon 442723, South Korea, T: +82-10-249-8303,
Ann Saudi Med. 2016 Sep-Oct;36(5):334-340. doi: 10.5144/0256-4947.2016.334.
Prediabetes is associated with an increased risk of cardiovascular disease (CVD). While the association of impaired glucose tolerance with CVD has been shown in many studies, the relationship between impaired fasting glucose (IFG) and CVD remains unclear.
The purpose of this study was to compare the coronary artery calcium (CAC) scores of participants with normal fasting glucose versus those with IFG, according to fasting plasma glucose (FPG) levels, and to assess whether differences in CAC scores were independent of important confounders.
Retrospective study.
Health Promotion Center of the University Hospital (Gyeonggi-do, South Korea), during the period 2010-2014.
Participants were enrolled from the general population who visited for a medical check-up. CAC was assessed in asymptomatic individuals by multidetector computed tomography. Anthropometric parameters and metabolic profiles were also recorded. Subjects were divided into four fasting glucose groups. Participants with a history of CVD or diabetes mellitus were excluded.
Correlation between FPG and CAC scores, CAC score categories, and association between CAC score and FPG categories.
Of 1112 participants, 346 (34.2%) had a CAC score > 0. FPG values in the IFG patients were positively but weakly correlated with CAC scores (r=0.099, P=.001). The incidence of CAC differed according to FPG level (P < .001) and in Kruskal-Wallis test the mean CAC score differed by FPG group (P < .001). After adjustment for other factors in a multiple logistic regression analysis, those subjects with FPG >=110 mg/dL had a significantly higher risk of CAC than did subjects with normal fasting glucose (110.
糖尿病前期与心血管疾病（CVD）风险增加相关。虽然许多研究已表明糖耐量受损与CVD之间的关联，但空腹血糖受损（IFG）与CVD之间的关系仍不明确。
本研究的目的是根据空腹血糖（FPG）水平，比较空腹血糖正常的参与者与IFG参与者的冠状动脉钙化（CAC）评分，并评估CAC评分的差异是否独立于重要的混杂因素。
回顾性研究。
2010 - 2014年期间，韩国京畿道大学医院健康促进中心。
参与者从前来进行体检的普通人群中招募。通过多排螺旋计算机断层扫描对无症状个体进行CAC评估。还记录了人体测量参数和代谢谱。受试者被分为四个空腹血糖组。排除有CVD或糖尿病病史的参与者。
FPG与CAC评分之间的相关性、CAC评分类别以及CAC评分与FPG类别之间的关联。
在1112名参与者中，346名（34.2%）的CAC评分>0。IFG患者的FPG值与CAC评分呈正相关但较弱（r = 0.099，P = 0.001）。CAC的发生率根据FPG水平而有所不同（P < 0.001），在Kruskal - Wallis检验中，平均CAC评分因FPG组而异（P < 0.001）。在多因素逻辑回归分析中对其他因素进行调整后，FPG≥110 mg/dL的受试者患CAC的风险显著高于空腹血糖正常的受试者（110... （原文此处似乎不完整）
