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Effect of the factor Xa inhibitor rivaroxaban on arterial thrombosis in wild-type and apolipoprotein E-deficient mice.利伐沙班对野生型和载脂蛋白 E 缺陷型小鼠动脉血栓形成的影响。
Thromb Res. 2012 Nov;130(5):793-8. doi: 10.1016/j.thromres.2012.01.002. Epub 2012 Jan 26.
2
Arterial antithrombotic activity of rivaroxaban, an orally active factor Xa inhibitor, in a rat electrolytic carotid artery injury model of thrombosis.利伐沙班(一种口服活性Xa因子抑制剂)在大鼠颈动脉血栓形成电解损伤模型中的动脉抗血栓活性。
Blood Coagul Fibrinolysis. 2011 Dec;22(8):720-6. doi: 10.1097/MBC.0b013e32834cb30e.
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Fibrin clot structure and function: a role in the pathophysiology of arterial and venous thromboembolic diseases.纤维蛋白凝块的结构和功能:在动脉和静脉血栓栓塞性疾病的病理生理学中的作用。
Arterioscler Thromb Vasc Biol. 2011 Dec;31(12):e88-99. doi: 10.1161/ATVBAHA.111.230631. Epub 2011 Aug 11.
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Rivaroxaban versus warfarin in nonvalvular atrial fibrillation.利伐沙班与华法林用于非瓣膜性心房颤动。
N Engl J Med. 2011 Sep 8;365(10):883-91. doi: 10.1056/NEJMoa1009638. Epub 2011 Aug 10.
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Venous and arterial thrombosis--pathogenesis and the rationale for anticoagulation.静脉和动脉血栓形成——发病机制和抗凝治疗的原理。
Thromb Haemost. 2011 Apr;105(4):586-96. doi: 10.1160/TH10-10-0683. Epub 2011 Jan 12.
6
Oral rivaroxaban for symptomatic venous thromboembolism.口服利伐沙班治疗有症状的静脉血栓栓塞症。
N Engl J Med. 2010 Dec 23;363(26):2499-510. doi: 10.1056/NEJMoa1007903. Epub 2010 Dec 3.
7
Acute ST-segment elevation myocardial infarction: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition).急性ST段抬高型心肌梗死:美国胸科医师学会循证临床实践指南(第8版)
Chest. 2008 Jun;133(6 Suppl):708S-775S. doi: 10.1378/chest.08-0665.
8
Triggers, targets and treatments for thrombosis.血栓形成的触发因素、靶点及治疗方法。
Nature. 2008 Feb 21;451(7181):914-8. doi: 10.1038/nature06797.
9
Inter-Society Consensus for the Management of Peripheral Arterial Disease (TASC II).外周动脉疾病管理跨学会共识(TASC II)
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使用利伐沙班作为足弓动脉血栓形成患者的溶栓治疗,血管内治疗效果欠佳

Using Rivaroxaban as Thrombolytic Treatment for a Patient of Pedal Arch Arterial Thrombosis with Suboptimal Result of Endovascular Therapy.

作者信息

Lee Hsin-Fu, Chan Yi-Hsin, Wang Chun-Li

机构信息

Cardiovascular Division, Department of Internal Medicine; ; Cardiovascular Intervention Center, Chang Gung Memorial Hospital, Linkou, Kweishan Hsiang, Taoyuan, Taiwan.

Cardiovascular Division, Department of Internal Medicine.

出版信息

Acta Cardiol Sin. 2016 Sep;32(5):623-626. doi: 10.6515/acs20151229a.

DOI:10.6515/acs20151229a
PMID:27713614
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5052484/
Abstract

A 77-year-old male with subacute right foot ischemia was treated with endovascular therapy to relieve total thrombosis of the pedal arch extending from the dorsalis pedis of the anterior tibial artery into the posterior tibial artery, plantar segment. Because the procedure was only partially successful, rivaroxaban was used for thrombolytic treatment resulting in improvement of the patient's ischemic pain and avoidance of gangrenous progression and surgical amputation. This is the first report describing successful recanalization of pedal arch arterial thrombosis using rivaroxaban in a patient after suboptimal results of endovascular therapy.

摘要

一名77岁男性患有亚急性右足缺血,接受了血管内治疗,以缓解从胫前动脉足背延伸至胫后动脉足底段的足弓完全血栓形成。由于该手术仅部分成功,因此使用利伐沙班进行溶栓治疗,从而改善了患者的缺血性疼痛,避免了坏疽进展和手术截肢。这是第一份报告,描述了在血管内治疗效果欠佳的患者中使用利伐沙班成功再通足弓动脉血栓形成的情况。