Herrera Oscar R, Christensen Michael L, Helms Richard A
Department of Clinical Pharmacy, University of Tennessee Health Science Center College of Pharmacy, Memphis, Tennessee ; State of Tennessee Center of Excellence in Pediatric Pharmacokinetics and Therapeutics, Memphis, Tennessee.
Department of Clinical Pharmacy, University of Tennessee Health Science Center College of Pharmacy, Memphis, Tennessee ; State of Tennessee Center of Excellence in Pediatric Pharmacokinetics and Therapeutics, Memphis, Tennessee ; Department of Pediatrics, University of Tennessee Health Science Center, Memphis, Tennessee.
J Pediatr Pharmacol Ther. 2016 Jul-Aug;21(4):308-321. doi: 10.5863/1551-6776-21.4.308.
As seen over the past 20 years, calprotectin has evolved as a novel, non-invasive biomarker of gastrointestinal (GI) inflammation. We present this review of calprotectin in pediatrics. This article will focus on studies using calprotectin concentrations from different body fluids to monitor inflammation in different disease states and conditions. The ultimate goal of our group is to lay down a foundation as we consider using calprotectin prospectively as a marker of intestinal inflammation that could lead to further testing and possibly a marker of preparedness for feeding. We surveyed all published studies in English of calprotectin in neonates, infants, children, and adolescents through February 2014. We will discuss calprotectin's basic properties and analysis such as characteristics, identification, presence in body fluids, and maturational development. In addition, calprotectin's use in inflammatory diseases exploring both GI and non-GI conditions will be evaluated and compared with other serum markers presently available. Finally, a summary of our findings and discussion of future work that could be undertaken in order to render calprotectin as a more useful monitoring tool to the medical research community will complete the review.
在过去20年中，钙卫蛋白已发展成为一种新型的、用于监测胃肠道（GI）炎症的非侵入性生物标志物。我们在此对儿科领域的钙卫蛋白进行综述。本文将重点关注利用来自不同体液的钙卫蛋白浓度来监测不同疾病状态下炎症的研究。我们团队的最终目标是奠定基础，以便前瞻性地将钙卫蛋白用作肠道炎症的标志物，这可能会带来进一步的检测，并有可能成为喂养准备情况的标志物。我们检索了截至2014年2月所有以英文发表的关于新生儿、婴儿、儿童和青少年钙卫蛋白的研究。我们将讨论钙卫蛋白的基本特性和分析，如特征、鉴定、在体液中的存在情况以及成熟发育。此外，还将评估钙卫蛋白在探索胃肠道和非胃肠道疾病的炎症性疾病中的应用，并与目前可用的其他血清标志物进行比较。最后，我们将总结研究结果，并讨论为使钙卫蛋白成为医学研究界更有用的监测工具而可能开展的未来工作，以此完成本综述。
