Ding Hao, Yang Qian, Shang Kun, Lan Hailian, Lv Jie, Liu Zhilin, Liu Yang, Sheng Lixing, Zeng Yanjun
Biomechanics and Medical Information Institute, Beijing University of Technology, Beijing, China.
Cardiol J. 2017;24(5):530-538. doi: 10.5603/CJ.a2016.0084. Epub 2016 Oct 7.
This study was aimed at developing a myocardial bridge-mural coronary artery simulative device and analyzing the relationship between shear stress on the mural coronary artery and atherosclerosis.
A myocardial bridge-mural coronary artery simulative device was used to simulate experiments in vitro. In the condition of maintaining any related parameters such as system temperature, average flow rate, and heart rate, we calculated and observed changes in proximal and distal mean values, and oscillatory value of shear stress on the mural coronary artery by regulating the compression level of the myocardial bridge to the mural coronary artery.
Under 0% compression, no significant differences were observed in distal and proximal mean values and oscillatory value of the shear stress on the mural coronary artery. With the increase in the degree of compression, the mean shear stress at the distal end was greater than that at the proximal end, but the oscillatory value of the shear stress at the proximal end was greater than that at the distal end.
The experimental results of this study indicate that myocardial bridge compression leads to abnormal hemodynamics at the proximal end of the mural coronary artery. This abnormal phenomenon is of great significance in the study of atherosclerosis hemodynamic pathogenesis, which has potential clinical value for pathological effects and treatments of myocardial bridge.
本研究旨在研发一种心肌桥-壁冠状动脉模拟装置，并分析壁冠状动脉上的剪切应力与动脉粥样硬化之间的关系。
使用心肌桥-壁冠状动脉模拟装置进行体外模拟实验。在保持系统温度、平均流速和心率等任何相关参数的条件下，通过调节心肌桥对壁冠状动脉的压迫程度，计算并观察壁冠状动脉近端和远端平均值以及剪切应力振荡值的变化。
在0%压迫下，壁冠状动脉上的剪切应力远端和近端平均值以及振荡值未观察到显著差异。随着压迫程度的增加，远端平均剪切应力大于近端，但近端剪切应力振荡值大于远端。
本研究的实验结果表明，心肌桥压迫导致壁冠状动脉近端血流动力学异常。这种异常现象在动脉粥样硬化血流动力学发病机制研究中具有重要意义，对心肌桥的病理影响及治疗具有潜在临床价值。
