Nikolić Dalibor, Radović Miloš, Aleksandrić Srđan, Tomašević Miloje, Filipović Nenad
Faculty of Engineering, University of Kragujevac, Sestre Janjic 6, 34000 Kragujevac, Serbia; Bioengineering Research and Development Center - BioIRC, Prvoslava Stojanovića 6, 34000 Kragujevac, Serbia.
Clinic of Cardiology Clinical Center of Serbia, Visegradska 26, 11000 Belgrade, Serbia.
Comput Methods Programs Biomed. 2014 Nov;117(2):137-44. doi: 10.1016/j.cmpb.2014.07.012. Epub 2014 Aug 12.
This study was performed to evaluate the influences of the myocardial bridges on the plaque initializations and progression in the coronary arteries. The wall structure is changed due to the plaque presence, which could be the reason for multiple heart malfunctions. Using simplified parametric finite element model (FE model) of the coronary artery having myocardial bridge and analyzing different mechanical parameters from blood circulation through the artery (wall shear stress, oscillatory shear index, residence time), we investigated the prediction of "the best" position for plaque progression. We chose six patients from the angiography records and used data from DICOM images to generate FE models with our software tools for FE preprocessing, solving and post-processing. We found a good correlation between real positions of the plaque and the ones that we predicted to develop at the proximal part of the myocardial bridges with wall shear stress, oscillatory shear index and residence time. This computer model could be additional predictive tool for everyday clinical examination of the patient with myocardial bridge.
本研究旨在评估心肌桥对冠状动脉斑块形成及进展的影响。由于斑块的存在，血管壁结构发生改变，这可能是多种心脏功能障碍的原因。通过使用具有心肌桥的冠状动脉简化参数有限元模型（FE模型），并分析从动脉血液循环中获取的不同力学参数（壁面剪应力、振荡剪切指数、停留时间），我们研究了斑块进展“最佳”位置的预测。我们从血管造影记录中选取了6名患者，并使用来自DICOM图像的数据，通过我们用于FE预处理、求解和后处理的软件工具生成FE模型。我们发现斑块的实际位置与我们预测在心肌桥近端因壁面剪应力、振荡剪切指数和停留时间而形成的位置之间存在良好的相关性。该计算机模型可为心肌桥患者的日常临床检查提供额外的预测工具。
