Scheepers Giel H, Lycklama A Nijeholt Jelger A, Poolman Bert
Department of Biochemistry, Groningen Biomolecular Sciences and Biotechnology Institute, Zernike Institute for Advanced Materials, University of Groningen, The Netherlands.
FEBS Lett. 2016 Dec;590(23):4393-4401. doi: 10.1002/1873-3468.12445. Epub 2016 Oct 23.
Substrate-binding proteins (SBPs) play an important role in solute uptake and signal transduction. In 2010, Berntsson et al. classified the 114 organism-specific SBP structures available at that time and defined six protein clusters, based on their structural similarity. Since then, the number of unique SBP structures has increased almost fivefold, whereas the number of protein entries in the Protein Data Bank (PDB) nearly doubled. On the basis of the much larger dataset, we now subclassify the SBPs within the original clusters. Moreover, we propose a 7th cluster based on a small group of SBPs with structural features significantly different from those observed in the other proteins.
底物结合蛋白（SBPs）在溶质摄取和信号转导中发挥着重要作用。2010年，伯恩特松等人对当时可用的114种生物体特异性SBP结构进行了分类，并根据它们的结构相似性定义了六个蛋白质簇。从那时起，独特SBP结构的数量几乎增加了五倍，而蛋白质数据库（PDB）中的蛋白质条目数量几乎翻了一番。基于这个大得多的数据集，我们现在对原始簇中的SBPs进行了子类划分。此外，我们基于一小群具有与其他蛋白质显著不同结构特征的SBPs提出了第7个簇。
