Slabber Cathryn A, Grimmer Craig D, Robinson Ross S
School of Chemistry and Physics, University of KwaZulu-Natal , Pietermaritzburg, South Africa 3209.
J Nat Prod. 2016 Oct 28;79(10):2726-2730. doi: 10.1021/acs.jnatprod.6b00726. Epub 2016 Oct 7.
NAMFIS (NMR Analysis of Molecular Flexibility In Solution) has been applied to curcumin dissolved in DMSO. Quantitative H-H distance constraints reduce a pool of candidate conformations to a solution collection of four enol conformations-two of these match curcumin crystallized with human transthyretin, and one is closely related to a single-crystal structure of curcumin.
NAMFIS（溶液中分子柔韧性的核磁共振分析）已应用于溶解在二甲基亚砜中的姜黄素。定量的H-H距离限制将候选构象库减少到四个烯醇构象的溶液集合——其中两个与与人转甲状腺素蛋白结晶的姜黄素相匹配，另一个与姜黄素的单晶结构密切相关。
