Biţă Andrei, Scorei Ion Romulus, Mogoantă Laurenţiu, Bejenaru Cornelia, Mogoşanu George Dan, Bejenaru Ludovic Everard
BioBoron Research Institute, S.C. Natural Research S.R.L., Podari, Dolj County, Romania;
Rom J Morphol Embryol. 2020 Apr-Jun;61(2):321-334. doi: 10.47162/RJME.61.2.02.
Coronaviruses (CoVs) represent a family of viruses that have numerous animal hosts, and they cause severe respiratory, as well as systemic and enteric infections, in humans. Currently, there are limited antiviral strategies for treating patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The lack of specific antiviral medicines and SARS-CoV-2 vaccines continues to aggravate the situation. Natural product-based antiviral drugs have been used in the two previous CoV outbreaks: Middle East respiratory syndrome coronavirus (MERS-CoV) and the first SARS-CoV. This review emphasizes the role of natural and semisynthetic candidate molecules for coronavirus disease 2019 (COVID-19) prophylaxis and treatment. The experimental evidence suggests that nature could offer huge possibilities for treatment of the COVID-19 pandemic.
冠状病毒（CoVs）是一类拥有众多动物宿主的病毒家族，它们可导致人类严重的呼吸道感染以及全身性和肠道感染。目前，针对感染严重急性呼吸综合征冠状病毒2（SARS-CoV-2）的患者，抗病毒治疗策略有限。缺乏特异性抗病毒药物和SARS-CoV-2疫苗的情况持续加剧这一局面。在前两次冠状病毒爆发中，即中东呼吸综合征冠状病毒（MERS-CoV）和首次出现的严重急性呼吸综合征冠状病毒（SARS-CoV）爆发期间，基于天然产物的抗病毒药物已被使用。本综述强调了天然和半合成候选分子在2019冠状病毒病（COVID-19）预防和治疗中的作用。实验证据表明，自然界可为应对COVID-19大流行提供巨大的治疗可能性。
