Department of Oral Pathology and Medicine, Dental School, University of Athens, Athens, Greece.
Dental School, University of Athens, Athens, Greece.
Oral Dis. 2017 Oct;23(7):828-839. doi: 10.1111/odi.12589. Epub 2016 Nov 24.
To date, there is a major effort in deciphering the role of complex microbial communities, especially the oral and gut microbiomes, in the pathogenesis of various diseases. Increasing evidence indicates a key role for the oral microbiome in autoimmune diseases. In this review article, we discuss links of the oral microbiota to a group of autoimmune diseases, that is, Sjögren's syndrome (SS), systemic lupus erythematosus (SLE), Crohn's disease (CD), and rheumatoid arthritis (RA). We particularly focus on factors that affect the balance between the immune system and the composition of microbiota leading to dysbiosis, loss of tolerance and subsequent autoimmune disease progression and maintenance.
迄今为止，人们在努力解析复杂微生物群落（尤其是口腔和肠道微生物群）在各种疾病发病机制中的作用。越来越多的证据表明口腔微生物群在自身免疫性疾病中起着关键作用。在这篇综述文章中，我们讨论了口腔微生物群与一组自身免疫性疾病（即干燥综合征、系统性红斑狼疮、克罗恩病和类风湿关节炎）之间的联系。我们特别关注影响免疫系统和微生物群落组成之间平衡的因素，这些因素会导致微生态失调、耐受性丧失以及随后的自身免疫性疾病进展和维持。
