Tchamdja E, Kulo A E, Akoda K, Teko-Agbo A, Assoumy A M, Niang E M M, Batawui K, Adomefa K, Bankolé A A, Kombiagou K, Hoppenheit A, Clausen P-H, Mattioli R C, Peter R, Napier G B, De Deken R, Marcotty T, Van Den Abbeele J, Delespaux V
Direction de l'Elevage, Lomé, BP 4041 Togo.
Ecole Supérieure d'Agronomie, Université de Lomé, BP 1515 Lomé, Togo.
Prev Vet Med. 2016 Apr 1;126:151-8. doi: 10.1016/j.prevetmed.2016.02.001. Epub 2016 Feb 4.
Trypanocidal drugs remain the most accessible and thus commonly used means of controlling tsetse transmitted animal African trypanosomosis. In Togo, trypanocides are sold on official as well as unofficial markets, but the quality of these trypanocides is undocumented so a drug quality assessment study was conducted from May 2013 to June 2014. Trypanocides supplied by European, Indian and Chinese pharmaceutical companies and sold on official and unofficial markets in Togo were purchased. In total fifty-two trypanocides were obtained, 24 of these samples from official markets and 28 from unofficial markets made up of a total of 36 diminazene diaceturate and 16 isometamidium chloride hydrochloride samples. The samples were analysed in the reference laboratory of the OIE (World Organisation for Animal Health), Laboratory for the Control of Veterinary Medicines (LACOMEV) in Dakar which uses galenic testing and high performance liquid chromatography (HPLC) testing as standard reference analysis methods. The results revealed a high proportion of trypanocides of sub-standard quality on the Togolese market: 40% were non-compliant to these quality reference standards. All of the HPLC non-compliant samples contained lower amounts of active ingredient compared to the concentration specified on the packaging. Non-compliance was higher in samples from the unofficial (53.57%) than from the official markets (25%; p=0.04).The main drug manufacturers, mostly of French origin in the study area, supply quality drugs through the official legal distribution circuit. Products of other origins mostly found on illegal markets present a significantly lower quality.
杀锥虫药物仍然是控制采采蝇传播的动物非洲锥虫病最容易获得且因此常用的手段。在多哥，杀锥虫剂在官方和非官方市场均有销售，但这些杀锥虫剂的质量并无记录，因此在2013年5月至2014年6月期间开展了一项药物质量评估研究。购买了由欧洲、印度和中国制药公司供应并在多哥官方和非官方市场销售的杀锥虫剂。总共获得了52种杀锥虫剂，其中24个样本来自官方市场，28个来自非官方市场，共有36个双乙酰氨苯脒样本和16个盐酸异美汀样本。这些样本在达喀尔的世界动物卫生组织（OIE）参考实验室——兽药控制实验室（LACOMEV）进行分析，该实验室使用盖伦检验和高效液相色谱（HPLC）检验作为标准参考分析方法。结果显示，多哥市场上不合格质量的杀锥虫剂比例很高：40%不符合这些质量参考标准。与包装上规定的浓度相比，所有HPLC不合格的样本所含活性成分的量都较低。非官方市场样本的不合格率（53.57%）高于官方市场样本（25%；p = 0.04）。主要药品制造商大多来自研究区域的法国，通过官方合法分销渠道供应质量合格的药品。在非法市场上发现的其他产地的产品质量明显较低。
