阿尔茨海默病及其日益蔓延的流行态势：风险因素、生物标志物以及对治疗方法的迫切需求。
Alzheimer Disease and Its Growing Epidemic: Risk Factors, Biomarkers, and the Urgent Need for Therapeutics.
作者信息
Hickman Richard A, Faustin Arline, Wisniewski Thomas
机构信息
Department of Pathology, New York University School of Medicine, Alexandria ERSP, 450 East 29th Street, New York, NY 10016, USA.
Department of Pathology, The Center for Cognitive Neurology, New York University School of Medicine, Alexandria ERSP, 450 East 29th Street, New York, NY 10016, USA; Department of Neurology, The Center for Cognitive Neurology, New York University School of Medicine, Alexandria ERSP, 450 East 29th Street, New York, NY 10016, USA.
出版信息
Neurol Clin. 2016 Nov;34(4):941-953. doi: 10.1016/j.ncl.2016.06.009. Epub 2016 Aug 4.
Alzheimer disease (AD) represents one of the greatest medical challenges of this century; the condition is becoming increasingly prevalent worldwide and no effective treatments have been developed for this terminal disease. Because the disease manifests at a late stage after a long period of clinically silent neurodegeneration, knowledge of the modifiable risk factors and the implementation of biomarkers is crucial in the primary prevention of the disease and presymptomatic detection of AD, respectively. This article discusses the growing epidemic of AD and antecedent risk factors in the disease process. Disease biomarkers are discussed, and the implications that this may have for the treatment of this currently incurable disease.
阿尔茨海默病（AD）是本世纪最大的医学挑战之一；这种疾病在全球范围内日益普遍，且尚未开发出针对这种晚期疾病的有效治疗方法。由于该疾病在长期临床无症状的神经退行性变后才在晚期出现症状，因此了解可改变的风险因素以及实施生物标志物分别对于该疾病的一级预防和症状前检测至关重要。本文讨论了AD日益流行的情况以及疾病过程中的前期风险因素。还讨论了疾病生物标志物及其对这种目前无法治愈的疾病治疗可能产生的影响。
Zotero 插件