老年记忆障碍患者中维生素B6和维生素D缺乏症的共现情况。
Vitamin B6 and vitamin D deficiency co-occurrence in geriatric memory patients.
作者信息
Przybelski Anna G, Bendlin Barbara B, Jones Jana E, Vogt Nicholas M, Przybelski Robert J
机构信息
Wisconsin Alzheimer's Disease Research Center University of Wisconsin School of Medicine and Public Health Madison Wisconsin USA.
University of Wisconsin School of Pharmacy Psychoactive Pharmaceutical Investigation Madison Wisconsin USA.
出版信息
Alzheimers Dement (Amst). 2024 Jan 22;16(1):e12525. doi: 10.1002/dad2.12525. eCollection 2024 Jan-Mar.
INTRODUCTION
Vitamin B6 and D levels are not assessed routinely in geriatric memory patients. This study examined vitamin levels to determine the potential effects on cognition.
METHODS
A chart review was conducted of 203 consecutive patients over a 12-month period. Levels of vitamins B1, B6, B12, and D were obtained on the day of clinic to identify deficiencies. A mental status exam (Mini Mental State Examination [MMSE]) was also performed.
RESULTS
One hundred sixty-seven patients had one or more vitamin levels obtained on the day of clinical evaluation. Vitamin B6 deficiency was the most common (37.5%), followed by vitamin D deficiency (36.8%). A chi-square test revealed significant co-occurrence of deficiency of vitamins B6 and D ( < 0.001). Vitamin B6 and D deficiencies were associated with lower MMSE scores ( < 0.05).
DISCUSSION
Vitamin B6 and D deficiencies are common in geriatric patients. The coexistence of these vitamin deficiencies has a significant association with cognitive performance, indicating the clinical importance of monitoring and supplementation.
引言
老年记忆障碍患者通常不会常规检测维生素B6和D的水平。本研究检测了维生素水平，以确定其对认知的潜在影响。
方法
对连续12个月内的203例患者进行病历回顾。在门诊当天检测维生素B1、B6、B12和D的水平，以确定是否缺乏。同时进行了精神状态检查（简易精神状态检查表[MMSE]）。
结果
167例患者在临床评估当天检测了一种或多种维生素水平。维生素B6缺乏最为常见（37.5%），其次是维生素D缺乏（36.8%）。卡方检验显示维生素B6和D缺乏显著共存（<0.001）。维生素B6和D缺乏与较低的MMSE评分相关（<0.05）。
讨论
维生素B6和D缺乏在老年患者中很常见。这些维生素缺乏的共存与认知表现有显著关联，表明监测和补充的临床重要性。
Zotero 插件